Mechanism of formation of human calcium oxalate renal stones on Randall's plaque

Andrew Evan, Fredric L. Coe, James E. Lingeman, Youzhi Shao, Andre J. Sommer, Sharon B. Bledsoe, Jennifer C. Anderson, Elaine M. Worcester

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Although calcium oxalate (CaOx) renal stones are known to grow attached to renal papillae, and specifically to regions of papillae that contain Randall's plaque (interstitial apatite deposits), the mechanisms of stone overgrowth on plaque are not known. To investigate the problem, we have obtained biopsy specimens from two stone patients that included an attached stone along with its tissue base and have studied the ultrastructural features of the attachment point using light and transmission electron microscopy, Fourier transform infrared spectroscopy (μ-FTIR), and immunohistochemical analysis. The epithelium is disrupted at the attachment site. The denuded plaque that borders on the urinary space attracts an envelope of ribbon-like laminates of crystal and organic matrix arising from urine ions and molecules. Into the matrix of this ribbon grow amorphous apatite crystals that merge with and give way to the usual small apatite crystals imbedded in stone matrix; eventually CaOx crystals admix with apatite and become the predominant solid phase. Over time, urine calcium and oxalate ions gradually overgrow on the large crystals forming the attached stone.

Original languageEnglish
Pages (from-to)1315-1323
Number of pages9
JournalAnatomical Record
Volume290
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

renal calculi
Apatites
Calcium Oxalate
calcium oxalate
oxalate
apatite
crystals
calcium
Kidney
crystal
Urine
Ions
urine
matrix
ions
Fourier Transform Infrared Spectroscopy
Transmission Electron Microscopy
Fourier transform infrared spectroscopy
oxalates
Epithelium

Keywords

  • Histopathology
  • Kidney biopsy
  • Randall's plaque

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Ecology, Evolution, Behavior and Systematics
  • Biotechnology

Cite this

Evan, A., Coe, F. L., Lingeman, J. E., Shao, Y., Sommer, A. J., Bledsoe, S. B., ... Worcester, E. M. (2007). Mechanism of formation of human calcium oxalate renal stones on Randall's plaque. Anatomical Record, 290(10), 1315-1323. https://doi.org/10.1002/ar.20580

Mechanism of formation of human calcium oxalate renal stones on Randall's plaque. / Evan, Andrew; Coe, Fredric L.; Lingeman, James E.; Shao, Youzhi; Sommer, Andre J.; Bledsoe, Sharon B.; Anderson, Jennifer C.; Worcester, Elaine M.

In: Anatomical Record, Vol. 290, No. 10, 10.2007, p. 1315-1323.

Research output: Contribution to journalArticle

Evan, A, Coe, FL, Lingeman, JE, Shao, Y, Sommer, AJ, Bledsoe, SB, Anderson, JC & Worcester, EM 2007, 'Mechanism of formation of human calcium oxalate renal stones on Randall's plaque', Anatomical Record, vol. 290, no. 10, pp. 1315-1323. https://doi.org/10.1002/ar.20580
Evan A, Coe FL, Lingeman JE, Shao Y, Sommer AJ, Bledsoe SB et al. Mechanism of formation of human calcium oxalate renal stones on Randall's plaque. Anatomical Record. 2007 Oct;290(10):1315-1323. https://doi.org/10.1002/ar.20580
Evan, Andrew ; Coe, Fredric L. ; Lingeman, James E. ; Shao, Youzhi ; Sommer, Andre J. ; Bledsoe, Sharon B. ; Anderson, Jennifer C. ; Worcester, Elaine M. / Mechanism of formation of human calcium oxalate renal stones on Randall's plaque. In: Anatomical Record. 2007 ; Vol. 290, No. 10. pp. 1315-1323.
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