Mechanism of self-tolerance of γ/δ T cells in epithelial tissue

Terrence A. Barrett, Michalle L. Delvy, David M. Kennedy, Leo Lefrancois, Louis A. Matis, Alexander Dent, Stephen M. Hedrick, Jeffrey A. Bluestone

Research output: Contribution to journalArticle

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Abstract

The present study examined mechanisms of tolerance for T cell receptor γ/δ (TCR-γ/δ) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-γ/δ cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Ag-bearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-γ/δ cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.

Original languageEnglish (US)
Pages (from-to)65-70
Number of pages6
JournalJournal of Experimental Medicine
Volume175
Issue number1
StatePublished - 1992
Externally publishedYes

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Self Tolerance
Isoantigens
T-Cell Antigen Receptor
Epithelium
Lymphocytes
T-Lymphocytes
Clonal Anergy
Thymus Gland
Spleen

ASJC Scopus subject areas

  • Immunology

Cite this

Barrett, T. A., Delvy, M. L., Kennedy, D. M., Lefrancois, L., Matis, L. A., Dent, A., ... Bluestone, J. A. (1992). Mechanism of self-tolerance of γ/δ T cells in epithelial tissue. Journal of Experimental Medicine, 175(1), 65-70.

Mechanism of self-tolerance of γ/δ T cells in epithelial tissue. / Barrett, Terrence A.; Delvy, Michalle L.; Kennedy, David M.; Lefrancois, Leo; Matis, Louis A.; Dent, Alexander; Hedrick, Stephen M.; Bluestone, Jeffrey A.

In: Journal of Experimental Medicine, Vol. 175, No. 1, 1992, p. 65-70.

Research output: Contribution to journalArticle

Barrett, TA, Delvy, ML, Kennedy, DM, Lefrancois, L, Matis, LA, Dent, A, Hedrick, SM & Bluestone, JA 1992, 'Mechanism of self-tolerance of γ/δ T cells in epithelial tissue', Journal of Experimental Medicine, vol. 175, no. 1, pp. 65-70.
Barrett TA, Delvy ML, Kennedy DM, Lefrancois L, Matis LA, Dent A et al. Mechanism of self-tolerance of γ/δ T cells in epithelial tissue. Journal of Experimental Medicine. 1992;175(1):65-70.
Barrett, Terrence A. ; Delvy, Michalle L. ; Kennedy, David M. ; Lefrancois, Leo ; Matis, Louis A. ; Dent, Alexander ; Hedrick, Stephen M. ; Bluestone, Jeffrey A. / Mechanism of self-tolerance of γ/δ T cells in epithelial tissue. In: Journal of Experimental Medicine. 1992 ; Vol. 175, No. 1. pp. 65-70.
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