Mechanisms of bile formation, hepatic uptake, and biliary excretion

C. D. Klaassen, J. B. Watkins

Research output: Contribution to journalReview article

382 Scopus citations

Abstract

Biliary excretion of xenobiotics is a complex process involving uptake into liver cells, intracellular sequestration and/or biotransformation, and transport into bile. A description of liver morphology and the possible mechanisms of bile formation is included to aid in the understanding of how chemical and physiological factors affect bile flow, hepatic uptake, and biliary excretion. Enterohepatic circulation interferes with the biliary elimination of xenobiotics from the body. The considerable volume of information that has accumulated in recent years on the mechanisms of bile formation, hepatic uptake, and biliary excretion is discussed in this comprehensive review.

Original languageEnglish (US)
Pages (from-to)1-67
Number of pages67
JournalPharmacological Reviews
Volume36
Issue number1
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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