Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs

Shengmei Zhou, Lan Chen, Yasushi Miyauchi, Mizuho Miyauchi, Saibal Kar, Simon Kangavari, Michael C. Fishbein, Behrooz Sharifi, Peng-Sheng Chen

Research output: Contribution to journalArticle

224 Citations (Scopus)

Abstract

Cardiac nerve sprouting and sympathetic hyperinnervation after myocardial infarction (MI) both contribute to arrhythmogenesis and sudden death. However, the mechanisms responsible for nerve sprouting after MI are unclear. The expression of nerve growth factor (NGF), growth associated protein 43 (GAP43), and other nerve markers were studied at the infarcted site, the noninfarcted left ventricle free wall (LVFW), and the left stellate ganglion (LSG) at several time points (30 minutes to 1 month) after MI. Transcardiac (difference between coronary sinus and aorta) NGF levels were also assayed. Acute MI resulted in the immediate elevation of the transcardiac NGF concentration within 3.5 hours after MI, followed by the upregulation of cardiac NGF and GAP43 expression, which was earlier and more pronounced at the infarcted site than the noninfarcted LVFW. However, cardiac nerve sprouting and sympathetic hyperinnervation were more pronounced in the noninfarcted than the infarcted LVFW site and peaked at 1 week after MI. The NGF and GAP43 protein levels significantly increased in the LSG from 3 days (P

Original languageEnglish (US)
Pages (from-to)76-83
Number of pages8
JournalCirculation Research
Volume95
Issue number1
DOIs
StatePublished - Jul 9 2004
Externally publishedYes

Fingerprint

Nerve Growth Factor
Myocardial Infarction
Dogs
GAP-43 Protein
Stellate Ganglion
Heart Ventricles
Coronary Sinus
Sudden Death
Aorta
Up-Regulation
Proteins

Keywords

  • Nerve growth factor
  • Nerve sprouting
  • Sympathetic nerve
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs. / Zhou, Shengmei; Chen, Lan; Miyauchi, Yasushi; Miyauchi, Mizuho; Kar, Saibal; Kangavari, Simon; Fishbein, Michael C.; Sharifi, Behrooz; Chen, Peng-Sheng.

In: Circulation Research, Vol. 95, No. 1, 09.07.2004, p. 76-83.

Research output: Contribution to journalArticle

Zhou, S, Chen, L, Miyauchi, Y, Miyauchi, M, Kar, S, Kangavari, S, Fishbein, MC, Sharifi, B & Chen, P-S 2004, 'Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs', Circulation Research, vol. 95, no. 1, pp. 76-83. https://doi.org/10.1161/01.RES.0000133678.22968.e3
Zhou, Shengmei ; Chen, Lan ; Miyauchi, Yasushi ; Miyauchi, Mizuho ; Kar, Saibal ; Kangavari, Simon ; Fishbein, Michael C. ; Sharifi, Behrooz ; Chen, Peng-Sheng. / Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs. In: Circulation Research. 2004 ; Vol. 95, No. 1. pp. 76-83.
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