Mechanisms of chromosome behaviour during mitosis

Claire E. Walczak, Shang Cai, Alexey Khodjakov

Research output: Contribution to journalReview article

147 Scopus citations

Abstract

For over a century, scientists have strived to understand the mechanisms that govern the accurate segregation of chromosomes during mitosis. The most intriguing feature of this process, which is particularly prominent in higher eukaryotes, is the complex behaviour exhibited by the chromosomes. This behaviour is based on specific and highly regulated interactions between the chromosomes and spindle microtubules. Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity.

Original languageEnglish (US)
Pages (from-to)91-102
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume11
Issue number2
DOIs
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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