Mechanisms of drug-induced lupus III. Sex-specific differences in T cell homing may explain increased disease severity in female mice

Raymond Yung, Robert Williams, Kent Johnson, Carrie Phillips, Lloyd Stoolman, Sandra Chang, Bruce Richardson

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Objective. To determine if sex-specific differences in lymphocyte trafficking could contribute to increased disease severity in female mice. Methods. A lupus-like disease was induced by injecting male and female mice with procainamide-treated T cell clones. Trafficking was examined by labeling the injected cells with 51Cr or 5-chloromethylfluorescein diacetate. Results. Females developed more autoimmune liver disease and greater titers of anti-DNA antibodies than did males, and 2-7 times more cells accumulated in the female spleens. Splenectomy prevented the development of autoantibodies and renal and liver disease. Oophorectomy decreased the splenic homing, autoantibody titer, and liver disease severity, to levels found in males. Conclusion. T cells traffic differently to the spleen in male and female mice, and the spleen appears to be essential in the disease process. This suggests that differences in T cell homing could contribute to sex-specific disease severity in this murine model, and also possibly in human disease.

Original languageEnglish (US)
Pages (from-to)1334-1343
Number of pages10
JournalArthritis and Rheumatism
Volume40
Issue number7
DOIs
StatePublished - Jul 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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