Mechanisms of Leukocyte Production and Release. XII. A Comparative Assay of the Leukocytosis-Inducing Factor (LIF) and the Colony-Stimulating Factor (CSF)

Hal Broxmeyer, Gary Van Zant, James R. Zucali, Joseph Lobue, Albert S. Gordon

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Experiments are reported which suggest that separate physiological regulators exist for neutrophil production and release. Sera obtained 2 hr post-iv injection of 4.0 μg E. coli lipopolysaccharide contained both LIF and CSF activity, whereas sera obtained 27 hr after the last of two and the last of five daily ip injections of 100.0 μg E. coli lipopolysaccharide demonstrated only LIF activity. Using the Etoxate test, it was established that neither LIF nor CSF activity could be attributed to endotoxin contamination of test sera.

Original languageEnglish (US)
Pages (from-to)1262-1267
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume145
Issue number4
DOIs
StatePublished - Apr 1974
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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