Mechanisms of osteolytic and osteoblastic skeletal lesions

G. David Roodman, Theresa Guise

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lytic and blastic bone metastases represent extremes of a continuum, with most patients having a mixture of osteolytic and osteoblastic components in their lesions. This chapter provides the mechanisms responsible for osteolytic and osteoblastic metastasis, and also provides examples of how their identification has resulted in the development of new treatments for cancer in bone (CIB) patients. Multiple mechanisms contribute to tumor cells homing to bone and the subsequent development of bone lesions. Adhesion molecules expressed on tumor cells and cellular products from tumor cells also increase bone metastasis. In osteolytic metastasis and multiple myeloma (MM), the bone remodeling process is imbalanced, or uncoupled, with increased osteoclastic bone resorption driven by osteoclast-activating factors produced by the tumor cells, or by cells in the bone microenvironment in response to the tumor cells. Immune cell tumor cell interactions can suppress antitumor immune responses, and are an emerging therapeutic target for modulating the growth of tumors.

Original languageEnglish (US)
Title of host publicationPrimer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Publisherwiley
Pages739-742
Number of pages4
ISBN (Electronic)9781119266594
ISBN (Print)9781119266563
DOIs
StatePublished - Jan 1 2018

Keywords

  • Antitumor immune responses
  • Multiple myeloma
  • Osteoblastic metastasis
  • Osteolytic metastasis
  • Skeletal lesions

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Roodman, G. D., & Guise, T. (2018). Mechanisms of osteolytic and osteoblastic skeletal lesions. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 739-742). wiley. https://doi.org/10.1002/9781119266594.ch95