Mechanisms of solute transport following urinary diversion through intestinal segments: An experimental study with rats

M. O. Koch, W. S. McDougal, C. O. Thompson

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Abstract

This investigation employs an in vivo intestinal perfusion model in rats in order to study the mechanisms of intestinal electrolyte transport as it relates to the acidosis associated with urinary diversion. This investigation demonstrates that urinary ammonium is directly related to net sodium secretion and that chloride absorption is directly related to net bicarbonate secretion. The general mechanisms described are consistent with previously described mechanisms of intestinal electrolyte transport but demonstrate substantial differences in net directional movements compared to normal intestinal transport. This study provides a working model for further investigation and solutions to the management of the acidosis associated with urinary diversion.

Original languageEnglish (US)
Pages (from-to)1390-1394
Number of pages5
JournalJournal of Urology
Volume146
Issue number5
DOIs
StatePublished - Jan 1 1991

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Keywords

  • Urinary diversion, acidosis, electrolytes

ASJC Scopus subject areas

  • Urology

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