Mechanisms of sudden cardiac death

Michael Rubart-von der Lohe, Douglas P. Zipes

Research output: Contribution to journalArticle

330 Citations (Scopus)

Abstract

Despite recent advances in preventing sudden cardiac death (SCD) due to cardiac arrhythmia, its incidence in the population at large has remained unacceptably high. Better understanding of the interaction among various functional, structural, and genetic factors underlying the susceptibility to, and initiation of, fatal arrhythmias is a major goal and will provide new tools for the prediction, prevention, and therapy of SCD. Here, we review the role of aberrant intracellular Ca2+ handling, ionic imbalances associated with acute myocardial ischemia, neurohumoral changes, and genetic predisposition in the pathogenesis of SCD due to cardiac arrhythmia. Therapeutic measures to prevent SCD are also discussed.

Original languageEnglish
Pages (from-to)2305-2315
Number of pages11
JournalJournal of Clinical Investigation
Volume115
Issue number9
DOIs
StatePublished - Sep 2005

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Sudden Cardiac Death
Cardiac Arrhythmias
Genetic Predisposition to Disease
Myocardial Ischemia
Incidence
Therapeutics
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mechanisms of sudden cardiac death. / Rubart-von der Lohe, Michael; Zipes, Douglas P.

In: Journal of Clinical Investigation, Vol. 115, No. 9, 09.2005, p. 2305-2315.

Research output: Contribution to journalArticle

Rubart-von der Lohe, Michael ; Zipes, Douglas P. / Mechanisms of sudden cardiac death. In: Journal of Clinical Investigation. 2005 ; Vol. 115, No. 9. pp. 2305-2315.
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