Mechanisms of sudden cardiac death

Michael Rubart, Douglas P. Zipes

Research output: Contribution to journalReview articlepeer-review

348 Scopus citations


Despite recent advances in preventing sudden cardiac death (SCD) due to cardiac arrhythmia, its incidence in the population at large has remained unacceptably high. Better understanding of the interaction among various functional, structural, and genetic factors underlying the susceptibility to, and initiation of, fatal arrhythmias is a major goal and will provide new tools for the prediction, prevention, and therapy of SCD. Here, we review the role of aberrant intracellular Ca2+ handling, ionic imbalances associated with acute myocardial ischemia, neurohumoral changes, and genetic predisposition in the pathogenesis of SCD due to cardiac arrhythmia. Therapeutic measures to prevent SCD are also discussed.

Original languageEnglish (US)
Pages (from-to)2305-2315
Number of pages11
JournalJournal of Clinical Investigation
Issue number9
StatePublished - Sep 2005

ASJC Scopus subject areas

  • Medicine(all)

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