Mechanisms of Toxoplasma gondii persistence and latency

William J. Sullivan, Victoria Jeffers

Research output: Contribution to journalReview article

119 Scopus citations

Abstract

Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic disease, particularly in immunocompromised individuals. Central to its transmission and pathogenesis is the ability of the proliferative stage (tachyzoite) to convert into latent tissue cysts (bradyzoites). Encystment allows Toxoplasma to persist in the host and affords the parasite a unique opportunity to spread to new hosts without proceeding through its sexual stage, which is restricted to felids. Bradyzoite tissue cysts can cause reactivated toxoplasmosis if host immunity becomes impaired. A greater understanding of the molecular mechanisms orchestrating bradyzoite development is needed to better manage the disease. Here, we will review key studies that have contributed to our knowledge about this persistent form of the parasite and how to study it, with a focus on how cellular stress can signal for the reprogramming of gene expression needed during bradyzoite development.

Original languageEnglish (US)
Pages (from-to)717-733
Number of pages17
JournalFEMS Microbiology Reviews
Volume36
Issue number3
DOIs
StatePublished - May 2012

Keywords

  • Apicomplexa
  • Differentiation
  • Eukaryotic pathogen
  • Microbial persistence
  • Parasite
  • Stress response

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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