Abstract
Rearrangements of the mixed-lineage leukemia gene MLL1 (MLL, HRX, ALL1), the human homologue of the Drosophila gene trithorax, are associated with aggressive acute leukemias in both children and adults. Transformation by rearranged forms of MLL1, including in-frame fusion proteins, partial tandem duplications, and amplification of MLL1 through upregulation of Hox gene and cofactor expression apparently results in a block in hematopoietic differentiation. MLL1 regulates Hox gene expression via direct promoter binding and histone H3 Lys 4 methylation mediated by the intrinsic methyltransferase activity of the SET domain. Mll1 knockout leads to loss of Hox gene expression, defects in hematopoiesis, and embryonic lethality. A close homologue, MLL2 is amplified in some solid tumors. MLL2 also has histone H3 Lys 4 methyltransferase activity that is dependent on menin, a protein mutated in multiple neoplasia type I (MEN1) and which is required for normal Hox expression. These findings underscore the importance of the MLL histone methyltransferases in development and disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 235-254 |
| Number of pages | 20 |
| Journal | Critical Reviews in Eukaryotic Gene Expression |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2004 |
| Externally published | Yes |
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Keywords
- Histone methylation
- Hox genes
- Mixed-lineage leukemia
- Multiple endocrine neoplasia
ASJC Scopus subject areas
- Molecular Biology
- Genetics
Cite this
Mechanisms of transformation by MLL. / Hess, Jay.
In: Critical Reviews in Eukaryotic Gene Expression, Vol. 14, No. 4, 2004, p. 235-254.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanisms of transformation by MLL
AU - Hess, Jay
PY - 2004
Y1 - 2004
N2 - Rearrangements of the mixed-lineage leukemia gene MLL1 (MLL, HRX, ALL1), the human homologue of the Drosophila gene trithorax, are associated with aggressive acute leukemias in both children and adults. Transformation by rearranged forms of MLL1, including in-frame fusion proteins, partial tandem duplications, and amplification of MLL1 through upregulation of Hox gene and cofactor expression apparently results in a block in hematopoietic differentiation. MLL1 regulates Hox gene expression via direct promoter binding and histone H3 Lys 4 methylation mediated by the intrinsic methyltransferase activity of the SET domain. Mll1 knockout leads to loss of Hox gene expression, defects in hematopoiesis, and embryonic lethality. A close homologue, MLL2 is amplified in some solid tumors. MLL2 also has histone H3 Lys 4 methyltransferase activity that is dependent on menin, a protein mutated in multiple neoplasia type I (MEN1) and which is required for normal Hox expression. These findings underscore the importance of the MLL histone methyltransferases in development and disease.
AB - Rearrangements of the mixed-lineage leukemia gene MLL1 (MLL, HRX, ALL1), the human homologue of the Drosophila gene trithorax, are associated with aggressive acute leukemias in both children and adults. Transformation by rearranged forms of MLL1, including in-frame fusion proteins, partial tandem duplications, and amplification of MLL1 through upregulation of Hox gene and cofactor expression apparently results in a block in hematopoietic differentiation. MLL1 regulates Hox gene expression via direct promoter binding and histone H3 Lys 4 methylation mediated by the intrinsic methyltransferase activity of the SET domain. Mll1 knockout leads to loss of Hox gene expression, defects in hematopoiesis, and embryonic lethality. A close homologue, MLL2 is amplified in some solid tumors. MLL2 also has histone H3 Lys 4 methyltransferase activity that is dependent on menin, a protein mutated in multiple neoplasia type I (MEN1) and which is required for normal Hox expression. These findings underscore the importance of the MLL histone methyltransferases in development and disease.
KW - Histone methylation
KW - Hox genes
KW - Mixed-lineage leukemia
KW - Multiple endocrine neoplasia
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U2 - 10.1615/CritRevEukaryotGeneExpr.v14.i4.10
DO - 10.1615/CritRevEukaryotGeneExpr.v14.i4.10
M3 - Article
VL - 14
SP - 235
EP - 254
JO - Critical Reviews in Eukaryotic Gene Expression
JF - Critical Reviews in Eukaryotic Gene Expression
SN - 1045-4403
IS - 4
ER -