Mechanisms of vascular calcification in chronic kidney disease

Research output: Contribution to journalShort survey

300 Citations (Scopus)

Abstract

Vascular calcification is common in chronic kidney disease and associated with increased morbidity and mortality. Its mechanism is multifactorial and incompletely understood. Patients with chronic kidney disease are at risk for vascular calcification because of multiple risk factors that induce vascular smooth muscle cells to change into a chondrocyte or osteoblast-like cell; high total body burden of calcium and phosphorus due to abnormal bone metabolism; low levels of circulating and locally produced inhibitors; impaired renal excretion; and current therapies. Together these factors increase risk and complicate the management of vascular calcification.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalJournal of the American Society of Nephrology
Volume19
Issue number2
DOIs
StatePublished - Feb 1 2008

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Vascular Calcification
Chronic Renal Insufficiency
Body Burden
Risk Management
Chondrocytes
Osteoblasts
Vascular Smooth Muscle
Phosphorus
Smooth Muscle Myocytes
Calcium
Morbidity
Bone and Bones
Mortality
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Mechanisms of vascular calcification in chronic kidney disease. / Moe, Sharon M.; Chen, Neal X.

In: Journal of the American Society of Nephrology, Vol. 19, No. 2, 01.02.2008, p. 213-216.

Research output: Contribution to journalShort survey

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