Mechanisms of working memory dysfunction after mild and moderate TBI: Evidence from functional MRI and neurogenetics

Thomas W. McAllister, Laura A. Flashman, Brenna C. McDonald, Andrew J. Saykin

Research output: Contribution to journalReview article

191 Scopus citations

Abstract

Cognitive complaints are a frequent source of distress and disability after mild and moderate traumatic brain injury (TBI). While there are deficits in several cognitive domains, many aspects of these complaints and deficits suggest that problems in working memory (WM) play an important role. Functional imaging studies in healthy individuals have outlined the neural substrate of WM and have shown that regions important in WM circuitry overlap with regions commonly vulnerable to damage in TBI. Use of functional MRI (fMRI) in individuals with mild and moderate TBI suggests that they can have problems in the activation and allocation of WM, and several lines of evidence suggest that subtle alterations in central catecholantinergic sensitivity may underlie these problems. We review the evidence from fMRI and neurogenetic studies that support the role of catecholaminergic dysregulation in the etiology of WM complaints and deficits after mild and moderate TBI.

Original languageEnglish (US)
Pages (from-to)1450-1467
Number of pages18
JournalJournal of neurotrauma
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

Keywords

  • Catecholamines
  • Episodic memory
  • Functional MRI
  • Traumatic brain injury
  • Working memory

ASJC Scopus subject areas

  • Clinical Neurology

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