Mechanisms Underlying HIV-Associated Noninfectious Lung Disease

Rachel M. Presti, Sonia C. Flores, Brent E. Palmer, Jeffrey J. Atkinson, Catherine R. Lesko, Bryan Lau, Andrew P. Fontenot, Jesse Roman, John F. McDyer, Homer Twigg

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Pulmonary disease remains a primary source of morbidity and mortality in persons living with HIV (PLWH), although the advent of potent combination antiretroviral therapy has resulted in a shift from predominantly infectious to noninfectious pulmonary complications. PLWH are at high risk for COPD, pulmonary hypertension, and lung cancer even in the era of combination antiretroviral therapy. The underlying mechanisms of this are incompletely understood, but recent research in both human and animal models suggests that oxidative stress, expression of matrix metalloproteinases, and genetic instability may result in lung damage, which predisposes PLWH to these conditions. Some of the factors that drive these processes include tobacco and other substance use, direct HIV infection and expression of specific HIV proteins, inflammation, and shifts in the microbiome toward pathogenic and opportunistic organisms. Further studies are needed to understand the relative importance of these factors to the development of lung disease in PLWH.

Original languageEnglish (US)
Pages (from-to)1053-1060
Number of pages8
JournalChest
Volume152
Issue number5
DOIs
StatePublished - Nov 1 2017

Fingerprint

Lung Diseases
HIV
Lung Neoplasms
Human Immunodeficiency Virus Proteins
Lung
Microbiota
Matrix Metalloproteinases
Pulmonary Hypertension
Chronic Obstructive Pulmonary Disease
HIV Infections
Tobacco
Oxidative Stress
Animal Models
Inflammation
Morbidity
Mortality
Therapeutics
Research

Keywords

  • COPD
  • HIV
  • inflammation
  • lung cancer
  • pulmonary hypertension

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Presti, R. M., Flores, S. C., Palmer, B. E., Atkinson, J. J., Lesko, C. R., Lau, B., ... Twigg, H. (2017). Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. Chest, 152(5), 1053-1060. https://doi.org/10.1016/j.chest.2017.04.154

Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. / Presti, Rachel M.; Flores, Sonia C.; Palmer, Brent E.; Atkinson, Jeffrey J.; Lesko, Catherine R.; Lau, Bryan; Fontenot, Andrew P.; Roman, Jesse; McDyer, John F.; Twigg, Homer.

In: Chest, Vol. 152, No. 5, 01.11.2017, p. 1053-1060.

Research output: Contribution to journalReview article

Presti, RM, Flores, SC, Palmer, BE, Atkinson, JJ, Lesko, CR, Lau, B, Fontenot, AP, Roman, J, McDyer, JF & Twigg, H 2017, 'Mechanisms Underlying HIV-Associated Noninfectious Lung Disease', Chest, vol. 152, no. 5, pp. 1053-1060. https://doi.org/10.1016/j.chest.2017.04.154
Presti RM, Flores SC, Palmer BE, Atkinson JJ, Lesko CR, Lau B et al. Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. Chest. 2017 Nov 1;152(5):1053-1060. https://doi.org/10.1016/j.chest.2017.04.154
Presti, Rachel M. ; Flores, Sonia C. ; Palmer, Brent E. ; Atkinson, Jeffrey J. ; Lesko, Catherine R. ; Lau, Bryan ; Fontenot, Andrew P. ; Roman, Jesse ; McDyer, John F. ; Twigg, Homer. / Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. In: Chest. 2017 ; Vol. 152, No. 5. pp. 1053-1060.
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