Mechanisms underlying the reentrant circuit of atrioventricular nodal reentrant tachycardia in isolated canine atrioventricular nodal preparation using optical mapping

Jianyi Wu, Jiashin Wu, Jeffrey Olgin, John Miller, Douglas P. Zipes

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The reentrant pathways underlying different types of atrioventricular (AV) nodal reentrant tachycardia have not yet been elucidated. This study was performed to optically map Koch's triangle and surrounding atrial tissue in an isolated canine AV nodal preparation. Multiple preferential AV nodal input pathways were observed in all preparations (n = 22) with continuous (73%, n = 16) and discontinuous (27%, n = 6) AV nodal function curves (AVNFCs). AV nodal echo beats (EBs) were induced in 54% (12/22) of preparations. The reentrant circuit of the slow/fast EB (36%, n = 8) started as a block in fast pathway (FP) and a delay in slow pathway (SP) conduction to the compact AV node, then exited from the AV node to the FP, and rapidly returned to the SP through the atrial tissue located at the base of Koch's triangle. The reentrant circuit of the fast/slow EB (9%, n = 2) was in an opposite direction. In the slow/slow EB (9%, n = 2), anterograde conduction was over the intermediate pathway (IP) and retrograde conduction was over the SP. Unidirectional conduction block occurred at the junction between the AV node and its input pathways. Conduction over the IP smoothed the transition from the FP to the SP, resulting in a continuous AVNFC. A "jump" in AH interval resulted from shifting of anterograde conduction from the FP to the SP (n = 4) or abrupt conduction delay within the AV node through the FP (n = 2). These findings indicate that (1) multiple AV nodal anterograde pathways exist in all normal hearts; (2) atrial tissue is involved in reentrant circuits; (3) unidirectional block occurs at the interface between the AV node and its input pathways; and (4) the IP can mask the existence of FP and SP, producing continuous AVNFCs.

Original languageEnglish
Pages (from-to)1189-1195
Number of pages7
JournalCirculation Research
Volume88
Issue number11
StatePublished - Jun 8 2001

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Atrioventricular Nodal Reentry Tachycardia
Atrioventricular Node
Canidae
Masks

Keywords

  • Atrioventricular nodal reentrant tachycardia
  • Atrioventricular node
  • Optical mapping

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Mechanisms underlying the reentrant circuit of atrioventricular nodal reentrant tachycardia in isolated canine atrioventricular nodal preparation using optical mapping. / Wu, Jianyi; Wu, Jiashin; Olgin, Jeffrey; Miller, John; Zipes, Douglas P.

In: Circulation Research, Vol. 88, No. 11, 08.06.2001, p. 1189-1195.

Research output: Contribution to journalArticle

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abstract = "The reentrant pathways underlying different types of atrioventricular (AV) nodal reentrant tachycardia have not yet been elucidated. This study was performed to optically map Koch's triangle and surrounding atrial tissue in an isolated canine AV nodal preparation. Multiple preferential AV nodal input pathways were observed in all preparations (n = 22) with continuous (73{\%}, n = 16) and discontinuous (27{\%}, n = 6) AV nodal function curves (AVNFCs). AV nodal echo beats (EBs) were induced in 54{\%} (12/22) of preparations. The reentrant circuit of the slow/fast EB (36{\%}, n = 8) started as a block in fast pathway (FP) and a delay in slow pathway (SP) conduction to the compact AV node, then exited from the AV node to the FP, and rapidly returned to the SP through the atrial tissue located at the base of Koch's triangle. The reentrant circuit of the fast/slow EB (9{\%}, n = 2) was in an opposite direction. In the slow/slow EB (9{\%}, n = 2), anterograde conduction was over the intermediate pathway (IP) and retrograde conduction was over the SP. Unidirectional conduction block occurred at the junction between the AV node and its input pathways. Conduction over the IP smoothed the transition from the FP to the SP, resulting in a continuous AVNFC. A {"}jump{"} in AH interval resulted from shifting of anterograde conduction from the FP to the SP (n = 4) or abrupt conduction delay within the AV node through the FP (n = 2). These findings indicate that (1) multiple AV nodal anterograde pathways exist in all normal hearts; (2) atrial tissue is involved in reentrant circuits; (3) unidirectional block occurs at the interface between the AV node and its input pathways; and (4) the IP can mask the existence of FP and SP, producing continuous AVNFCs.",
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