Mechanistic Observations on the Role of the Stannous Ion in Caries Lesion De- and Remineralization

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4 Scopus citations


Two mechanistic, laboratory, factorial design studies were conducted to investigate the effect of the stannous ion (Sn2+) in the absence or presence of fluoride on caries lesion de- and remineralization. Study I was concerned with determining changes in mineral distribution of subsurface lesions, whereas study II investigated changes in surface hardness of surface-softened lesions as a function of pH. Study I showed that Sn2+ modulates the effects of fluoride by preventing lamination. Study II revealed that the effect of Sn2+ on rehardening is pH dependent. Neither study demonstrated synergy between Sn2+ and fluoride, yet interactions were observed. Sn2+ does interfere with remineralization to some extent although it provided acid resistance. The role of Sn2+ in the caries process is complex.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalCaries Research
Issue number4
StatePublished - Sep 1 2016


  • Caries
  • Demineralization
  • Enamel
  • Fluoride
  • Remineralization
  • Stannous ion

ASJC Scopus subject areas

  • Dentistry(all)

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