Mechano-rheological properties of the murine thrombus determined via nanoindentation and finite element modeling

Constance L. Slaboch, Mark S. Alber, Elliot D. Rosen, Timothy C. Ovaert

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Deep vein thrombosis, pulmonary embolism, and abdominal aortic aneurysms are blood-related diseases that represent a major public health problem. These diseases are characterized by the formation of a thrombus (i.e., blood clot) that either blocks a major artery or causes an aortic rupture. Identifying the mechanical properties of thrombi can help determine when these incidents will occur. In this investigation, a murine thrombus, formed from platelet-rich plasma, calcium, and thrombin, was nanoindented and the elastic modulus was estimated via elastic contact theory. This information was used as input to an inverse finite element simulation, which determined optimal values for the elastic modulus and viscosity of the thrombus using a viscoelastic material model. A sensitivity analysis was also performed to determine which material parameters have the greatest affect on the simulation. Results from this investigation demonstrate the feasibility of the mechanical characterization of a murine thrombus using nanoindentation.

Original languageEnglish (US)
Pages (from-to)75-86
Number of pages12
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume10
DOIs
StatePublished - Jun 1 2012

Keywords

  • Abdominal aortic aneurysms (AAA)
  • Deep vein thrombosis (DVT)
  • Mechanical response
  • Nanoindentation
  • Soft tissue characterization
  • Thrombi mechanics
  • Viscoelasticity

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Mechanics of Materials

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