Mechanobiology of trabecular meshwork cells

Darrell WuDunn

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Trabecular meshwork (TM) cells likely play a key role in regulating outflow facility and hence intraocular pressure. They function in a dynamic environment subjected to variations in mechanical and fluid shear forces. Because the extent of mechanical stress on the trabecular meshwork is dependent on the intraocular pressure, the behavior of TM cells under mechanical strain may suggest mechanisms for how outflow facility is regulated. Studies have demonstrated that TM cells respond in a variety of ways to mechanical loads, including increased extracellular matrix turnover, altered gene expression, cytokine release, and altered signal transduction. This review highlights some of the considerations and limitations of studying the mechanobiology of TM cells.

Original languageEnglish
Pages (from-to)718-723
Number of pages6
JournalExperimental Eye Research
Volume88
Issue number4
DOIs
StatePublished - Apr 30 2009

Fingerprint

Trabecular Meshwork
Biophysics
Intraocular Pressure
Mechanical Stress
Extracellular Matrix
Signal Transduction
Cytokines
Gene Expression

Keywords

  • biomechanics
  • extracellular matrix
  • mechanical strain
  • trabecular meshwork

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Mechanobiology of trabecular meshwork cells. / WuDunn, Darrell.

In: Experimental Eye Research, Vol. 88, No. 4, 30.04.2009, p. 718-723.

Research output: Contribution to journalArticle

WuDunn, Darrell. / Mechanobiology of trabecular meshwork cells. In: Experimental Eye Research. 2009 ; Vol. 88, No. 4. pp. 718-723.
@article{7ab3305104c747c19bea880055b6a858,
title = "Mechanobiology of trabecular meshwork cells",
abstract = "Trabecular meshwork (TM) cells likely play a key role in regulating outflow facility and hence intraocular pressure. They function in a dynamic environment subjected to variations in mechanical and fluid shear forces. Because the extent of mechanical stress on the trabecular meshwork is dependent on the intraocular pressure, the behavior of TM cells under mechanical strain may suggest mechanisms for how outflow facility is regulated. Studies have demonstrated that TM cells respond in a variety of ways to mechanical loads, including increased extracellular matrix turnover, altered gene expression, cytokine release, and altered signal transduction. This review highlights some of the considerations and limitations of studying the mechanobiology of TM cells.",
keywords = "biomechanics, extracellular matrix, mechanical strain, trabecular meshwork",
author = "Darrell WuDunn",
year = "2009",
month = "4",
day = "30",
doi = "10.1016/j.exer.2008.11.008",
language = "English",
volume = "88",
pages = "718--723",
journal = "Experimental Eye Research",
issn = "0014-4835",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Mechanobiology of trabecular meshwork cells

AU - WuDunn, Darrell

PY - 2009/4/30

Y1 - 2009/4/30

N2 - Trabecular meshwork (TM) cells likely play a key role in regulating outflow facility and hence intraocular pressure. They function in a dynamic environment subjected to variations in mechanical and fluid shear forces. Because the extent of mechanical stress on the trabecular meshwork is dependent on the intraocular pressure, the behavior of TM cells under mechanical strain may suggest mechanisms for how outflow facility is regulated. Studies have demonstrated that TM cells respond in a variety of ways to mechanical loads, including increased extracellular matrix turnover, altered gene expression, cytokine release, and altered signal transduction. This review highlights some of the considerations and limitations of studying the mechanobiology of TM cells.

AB - Trabecular meshwork (TM) cells likely play a key role in regulating outflow facility and hence intraocular pressure. They function in a dynamic environment subjected to variations in mechanical and fluid shear forces. Because the extent of mechanical stress on the trabecular meshwork is dependent on the intraocular pressure, the behavior of TM cells under mechanical strain may suggest mechanisms for how outflow facility is regulated. Studies have demonstrated that TM cells respond in a variety of ways to mechanical loads, including increased extracellular matrix turnover, altered gene expression, cytokine release, and altered signal transduction. This review highlights some of the considerations and limitations of studying the mechanobiology of TM cells.

KW - biomechanics

KW - extracellular matrix

KW - mechanical strain

KW - trabecular meshwork

UR - http://www.scopus.com/inward/record.url?scp=64249118693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64249118693&partnerID=8YFLogxK

U2 - 10.1016/j.exer.2008.11.008

DO - 10.1016/j.exer.2008.11.008

M3 - Article

VL - 88

SP - 718

EP - 723

JO - Experimental Eye Research

JF - Experimental Eye Research

SN - 0014-4835

IS - 4

ER -