Mediastinal Germ Cell Tumors: Updates in Diagnosis and Management

Amanda R. Stram, Kenneth A. Kesler

Research output: Contribution to journalReview articlepeer-review


Primary mediastinal nonseminomatous germ cell tumors represent a rare but important malignancy that occurs in otherwise young and healthy patients. Treatment is challenging and involves cisplatin-based chemotherapy followed by surgery to remove residual disease. Avoiding bleomycin-containing chemotherapy in the treatment of primary mediastinal nonseminomatous germ cell tumors is important. Prechemotherapy and postchemotherapy pathology as well as postoperative serum tumor markers are independent predictors of long-term survival.

Original languageEnglish (US)
Pages (from-to)571-579
Number of pages9
JournalSurgical Oncology Clinics of North America
Issue number4
StatePublished - Oct 2020


  • Chemotherapy
  • Germ cell tumors
  • Mediastinal tumors
  • Nonseminomatous germ cell cancer
  • Thoracic surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

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