Mediastinal yolk sac tumor: The Indiana University experience, 1976 to 1988

S. Saxman, C. R. Nichols, S. D. Williams, P. J. Loehrer, L. H. Einhorn

Research output: Contribution to journalArticle

11 Scopus citations


Mediastinal yolk sac tumor (endodermal sinus tumor) is an extremely rare extragonadal germ cell neoplasm that has been associated with a grave prognosis. Twenty-one male patients with mediastinal yolk sac tumor received treatment at Indiana University between 1976 and 1988. Fourteen were seen after initial diagnosis, and their disease was treated with cisplatin-based chemotherapy in association with complete surgical resection if possible. Five are currently alive and disease free (36%). Seven were referred for salvage chemotherapy after relapse of their disease. Despite aggressive chemotherapy, these patients all died; they had a median survival time of 6 months. Our experience suggests that an aggressive combined modality approach with cisplatin-based chemotherapy followed by surgical resection of residual disease is the optimal management of this tumor. New regimens need to be explored for relapse of the disease after initial chemotherapy.

Original languageEnglish (US)
Pages (from-to)913-916
Number of pages4
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number6
StatePublished - 1991

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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