Mediastinal yolk sac tumor

The Indiana University experience, 1976 to 1988

S. Saxman, C. R. Nichols, S. D. Williams, Patrick Loehrer, Lawrence Einhorn

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Mediastinal yolk sac tumor (endodermal sinus tumor) is an extremely rare extragonadal germ cell neoplasm that has been associated with a grave prognosis. Twenty-one male patients with mediastinal yolk sac tumor received treatment at Indiana University between 1976 and 1988. Fourteen were seen after initial diagnosis, and their disease was treated with cisplatin-based chemotherapy in association with complete surgical resection if possible. Five are currently alive and disease free (36%). Seven were referred for salvage chemotherapy after relapse of their disease. Despite aggressive chemotherapy, these patients all died; they had a median survival time of 6 months. Our experience suggests that an aggressive combined modality approach with cisplatin-based chemotherapy followed by surgical resection of residual disease is the optimal management of this tumor. New regimens need to be explored for relapse of the disease after initial chemotherapy.

Original languageEnglish
Pages (from-to)913-916
Number of pages4
JournalJournal of Thoracic and Cardiovascular Surgery
Volume102
Issue number6
StatePublished - 1991

Fingerprint

Endodermal Sinus Tumor
Drug Therapy
Cisplatin
Recurrence
Germ Cell and Embryonal Neoplasms
Survival
Neoplasms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Mediastinal yolk sac tumor : The Indiana University experience, 1976 to 1988. / Saxman, S.; Nichols, C. R.; Williams, S. D.; Loehrer, Patrick; Einhorn, Lawrence.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 102, No. 6, 1991, p. 913-916.

Research output: Contribution to journalArticle

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