Mediational factors underlying cognitive changes and laterality in affective illness

Linda R. Sapin, Wade H. Berrettini, John Nurnberger, Lawrence A. Rothblat

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Affective illness has been associated with lateralized right hemisphere deficits and global cognitive dysfunction. However, there has been very little exploration of informationprocessing strategies that may underlie cognitive changes in this population. Twenty euthymic, drug-free, bipolar patients and 20 controls were given a series of tasks to assess lateralized impairment of the cerebral hemispheres and sequential (analytic) versus simultaneous (gestalt) information-processing strategies. There were no differences between patients and controls in tests sensitive to right or left hemisphere impairment or in total errors on a face recognition task. However, patients tended to rely on individual facial features for recognition whereas controls were able to synthesize multiple elements of the faces. Moreover, on a task that required holistic synthesis of multiple stimulus elements (Street Gestalt Completion Test), patients made significantly more errors than controls. Implications for information-processing changes in bipolar affective illness are discussed.

Original languageEnglish (US)
Pages (from-to)979-986
Number of pages8
JournalBiological Psychiatry
Volume22
Issue number8
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Automatic Data Processing
Cerebrum
Pharmaceutical Preparations
Population
Cognitive Dysfunction
Facial Recognition

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Mediational factors underlying cognitive changes and laterality in affective illness. / Sapin, Linda R.; Berrettini, Wade H.; Nurnberger, John; Rothblat, Lawrence A.

In: Biological Psychiatry, Vol. 22, No. 8, 1987, p. 979-986.

Research output: Contribution to journalArticle

Sapin, Linda R. ; Berrettini, Wade H. ; Nurnberger, John ; Rothblat, Lawrence A. / Mediational factors underlying cognitive changes and laterality in affective illness. In: Biological Psychiatry. 1987 ; Vol. 22, No. 8. pp. 979-986.
@article{893dc0f480064332a32c6e6fc9518764,
title = "Mediational factors underlying cognitive changes and laterality in affective illness",
abstract = "Affective illness has been associated with lateralized right hemisphere deficits and global cognitive dysfunction. However, there has been very little exploration of informationprocessing strategies that may underlie cognitive changes in this population. Twenty euthymic, drug-free, bipolar patients and 20 controls were given a series of tasks to assess lateralized impairment of the cerebral hemispheres and sequential (analytic) versus simultaneous (gestalt) information-processing strategies. There were no differences between patients and controls in tests sensitive to right or left hemisphere impairment or in total errors on a face recognition task. However, patients tended to rely on individual facial features for recognition whereas controls were able to synthesize multiple elements of the faces. Moreover, on a task that required holistic synthesis of multiple stimulus elements (Street Gestalt Completion Test), patients made significantly more errors than controls. Implications for information-processing changes in bipolar affective illness are discussed.",
author = "Sapin, {Linda R.} and Berrettini, {Wade H.} and John Nurnberger and Rothblat, {Lawrence A.}",
year = "1987",
doi = "10.1016/0006-3223(87)90007-2",
language = "English (US)",
volume = "22",
pages = "979--986",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "8",

}

TY - JOUR

T1 - Mediational factors underlying cognitive changes and laterality in affective illness

AU - Sapin, Linda R.

AU - Berrettini, Wade H.

AU - Nurnberger, John

AU - Rothblat, Lawrence A.

PY - 1987

Y1 - 1987

N2 - Affective illness has been associated with lateralized right hemisphere deficits and global cognitive dysfunction. However, there has been very little exploration of informationprocessing strategies that may underlie cognitive changes in this population. Twenty euthymic, drug-free, bipolar patients and 20 controls were given a series of tasks to assess lateralized impairment of the cerebral hemispheres and sequential (analytic) versus simultaneous (gestalt) information-processing strategies. There were no differences between patients and controls in tests sensitive to right or left hemisphere impairment or in total errors on a face recognition task. However, patients tended to rely on individual facial features for recognition whereas controls were able to synthesize multiple elements of the faces. Moreover, on a task that required holistic synthesis of multiple stimulus elements (Street Gestalt Completion Test), patients made significantly more errors than controls. Implications for information-processing changes in bipolar affective illness are discussed.

AB - Affective illness has been associated with lateralized right hemisphere deficits and global cognitive dysfunction. However, there has been very little exploration of informationprocessing strategies that may underlie cognitive changes in this population. Twenty euthymic, drug-free, bipolar patients and 20 controls were given a series of tasks to assess lateralized impairment of the cerebral hemispheres and sequential (analytic) versus simultaneous (gestalt) information-processing strategies. There were no differences between patients and controls in tests sensitive to right or left hemisphere impairment or in total errors on a face recognition task. However, patients tended to rely on individual facial features for recognition whereas controls were able to synthesize multiple elements of the faces. Moreover, on a task that required holistic synthesis of multiple stimulus elements (Street Gestalt Completion Test), patients made significantly more errors than controls. Implications for information-processing changes in bipolar affective illness are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0023203721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023203721&partnerID=8YFLogxK

U2 - 10.1016/0006-3223(87)90007-2

DO - 10.1016/0006-3223(87)90007-2

M3 - Article

C2 - 3607138

AN - SCOPUS:0023203721

VL - 22

SP - 979

EP - 986

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 8

ER -