Medical care of girls with turner syndrome

Where are we lacking?

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To characterize the medical care of a large cohort of girls with Turner syndrome with a focus on changes in management since establishment of international consensus guidelines in 2007. Methods: We reviewed medical records of patients followed up for Turner syndrome between 2000 and 2010. Results: A total of 128 girls aged 13.2 ± 0.5 years were identified. Average age at diagnosis was 4.1 ± 5.1 years. Overall, medical assessments performed included a hearing test in 56%, thyroid screening in 95%, renal ultrasonography in 100%, and echocardiography in 100%. Before 2007, none of the patients had screening performed for celiac disease, dyslipidemia, or liver dysfunction, and none had routine electrocardiography or cardiac magnetic resonance imaging. Since 2007, 63% were screened for celiac disease, 54% for liver abnormalities, and 38% for dyslipidemia. Electrocardiography was performed in 23%, while cardiac magnetic resonance imaging was performed in 39%. Although conjugated equine oral estrogen was the main mode of estrogen replacement, a significant increase was noted in the use of transdermal estrogen during the past 2 years compared with that observed in the earlier interval (78% vs 10%, respectively). Conclusions: Although changes in medical practice have occurred since establishment of the international Turner syndrome guidelines, screening for associated comorbidities was deficient in greater than 50% of the patients in our study. This is the first study evaluating medical care in a large cohort of pediatric patients with Turner syndrome, and our findings emphasize the need for continual education of all physicians involved in the care of this population.

Original languageEnglish
Pages (from-to)747-752
Number of pages6
JournalEndocrine Practice
Volume17
Issue number5
DOIs
StatePublished - Sep 1 2011

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Turner Syndrome
Celiac Disease
Dyslipidemias
Electrocardiography
Magnetic Resonance Imaging
Hearing Tests
Guidelines
Conjugated (USP) Estrogens
Estrogen Replacement Therapy
Medical Records
Echocardiography
Comorbidity
Liver Diseases
Ultrasonography
Thyroid Gland
Estrogens
Pediatrics
Physicians
Kidney
Education

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Medical care of girls with turner syndrome : Where are we lacking? / Nabhan, Zeina; Eugster, Erica.

In: Endocrine Practice, Vol. 17, No. 5, 01.09.2011, p. 747-752.

Research output: Contribution to journalArticle

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abstract = "Objective: To characterize the medical care of a large cohort of girls with Turner syndrome with a focus on changes in management since establishment of international consensus guidelines in 2007. Methods: We reviewed medical records of patients followed up for Turner syndrome between 2000 and 2010. Results: A total of 128 girls aged 13.2 ± 0.5 years were identified. Average age at diagnosis was 4.1 ± 5.1 years. Overall, medical assessments performed included a hearing test in 56{\%}, thyroid screening in 95{\%}, renal ultrasonography in 100{\%}, and echocardiography in 100{\%}. Before 2007, none of the patients had screening performed for celiac disease, dyslipidemia, or liver dysfunction, and none had routine electrocardiography or cardiac magnetic resonance imaging. Since 2007, 63{\%} were screened for celiac disease, 54{\%} for liver abnormalities, and 38{\%} for dyslipidemia. Electrocardiography was performed in 23{\%}, while cardiac magnetic resonance imaging was performed in 39{\%}. Although conjugated equine oral estrogen was the main mode of estrogen replacement, a significant increase was noted in the use of transdermal estrogen during the past 2 years compared with that observed in the earlier interval (78{\%} vs 10{\%}, respectively). Conclusions: Although changes in medical practice have occurred since establishment of the international Turner syndrome guidelines, screening for associated comorbidities was deficient in greater than 50{\%} of the patients in our study. This is the first study evaluating medical care in a large cohort of pediatric patients with Turner syndrome, and our findings emphasize the need for continual education of all physicians involved in the care of this population.",
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