Medical management of motility disorders in patients with intestinal failure: A focus on necrotizing enterocolitis, gastroschisis, and intestinal atresia

Bryan J. Dicken, Consolato Sergi, Frederick J. Rescorla, Francine Breckler, David Sigalet

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Background: Intestinal failure (IF) is the dependence upon parenteral nutrition to maintain minimal energy requirements for growth and development. It may occur secondary to a loss of bowel length, disorders of motility, or both. Short bowel syndrome (SBS) is a malabsorptive state resulting from surgical resection, congenital defect, or diseases associated with loss of absorptive surface area. A particularly vexing problem is associated with whole bowel and/or segmental intestinal dysmotility. Motility disorders within the context of SBS and IF may relate to rapid intestinal transit secondary to loss of intestinal length, dysmotility associated with loss or poor antegrade peristalsis, or gastroparesis. Therapy may be classified into medical (prokinetic and antidiarrheal agents) and surgical to deal with the overdistended poorly motile bowel. Methods: We performed a systematic review of the literature pertaining to IF, SBS, and dysmotility in the pediatric population with gastroschisis, necrotizing enterocolitis, and intestinal atresia. In addition to the available treatment options, we have provided a review of the literature and a summary of the available evidence. Conclusion: Despite relatively poor level of evidence regarding the application of promotility and antidiarrheal medications in patients with SBS and IF, these agents continue to be used. Herein, we provide a review of the physiology and pathophysiology of intestinal motility/dysmotility and available strategies for the use of promotility and antidiarrheal agents in patients with IF/SBS.

Original languageEnglish (US)
Pages (from-to)1618-1630
Number of pages13
JournalJournal of Pediatric Surgery
Volume46
Issue number8
DOIs
StatePublished - Aug 1 2011

Keywords

  • Antidiarrheal agents
  • Dysmotility
  • Intestinal failure
  • Promotility agents
  • Short bowel syndrome

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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