Medical management of nocturnal symptoms of gastro-oesophageal reflux disease in the elderly

Samer Gawrieh, Reza Shaker

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Elderly patients with nocturnal symptoms of gastro-oesophageal reflux disease (GORD) usually experience a more aggressive and complicated disease course compared with younger patients, resulting in impaired quality of life. The severity of disease and possible complications should be evaluated with upper endoscopy once the diagnosis is suspected. Elderly patients with nocturnal symptoms of GORD and evidence of endoscopic complications (oesophagitis, Barrett's oesophagus, etc.) and those with severe endoscopically negative reflux disease (ENRD) should be treated with proton pump inhibitors. Histamine H2 receptor antagonists are suitable for mild-to-moderate ENRD. Antacids and lifestyle modifications may be incorporated into the management as adjuncts to more potent and durable therapeutic agents. Effective treatment of nocturnal GORD symptoms in the elderly will result in relief of symptoms, healing of oesophagitis and improved quality of life, and should be maintained indefinitely to prevent relapses of the disease.

Original languageEnglish (US)
Pages (from-to)509-516
Number of pages8
JournalDrugs and Aging
Volume20
Issue number7
DOIs
StatePublished - Jun 19 2003
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Medical management of nocturnal symptoms of gastro-oesophageal reflux disease in the elderly'. Together they form a unique fingerprint.

  • Cite this