Medical management of nocturnal symptoms of gastro-oesophageal reflux disease in the elderly

Samer Gawrieh, Reza Shaker

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Elderly patients with nocturnal symptoms of gastro-oesophageal reflux disease (GORD) usually experience a more aggressive and complicated disease course compared with younger patients, resulting in impaired quality of life. The severity of disease and possible complications should be evaluated with upper endoscopy once the diagnosis is suspected. Elderly patients with nocturnal symptoms of GORD and evidence of endoscopic complications (oesophagitis, Barrett's oesophagus, etc.) and those with severe endoscopically negative reflux disease (ENRD) should be treated with proton pump inhibitors. Histamine H2 receptor antagonists are suitable for mild-to-moderate ENRD. Antacids and lifestyle modifications may be incorporated into the management as adjuncts to more potent and durable therapeutic agents. Effective treatment of nocturnal GORD symptoms in the elderly will result in relief of symptoms, healing of oesophagitis and improved quality of life, and should be maintained indefinitely to prevent relapses of the disease.

Original languageEnglish (US)
Pages (from-to)509-516
Number of pages8
JournalDrugs and Aging
Volume20
Issue number7
DOIs
StatePublished - 2003
Externally publishedYes

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Esophageal Diseases
Gastroesophageal Reflux
Esophagitis
Quality of Life
Histamine H2 Antagonists
Antacids
Barrett Esophagus
Proton Pump Inhibitors
Endoscopy
Life Style
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Pharmacology

Cite this

Medical management of nocturnal symptoms of gastro-oesophageal reflux disease in the elderly. / Gawrieh, Samer; Shaker, Reza.

In: Drugs and Aging, Vol. 20, No. 7, 2003, p. 509-516.

Research output: Contribution to journalReview article

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