Medication compliance in elderly outpatients using twice-daily dosing and unit-of-use packaging

M. D. Murray, Michael Murray, A. K. Manatunga, J. C. Darnell, H. A. Monsanto, S. LaPlante

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To determine the effect of unit-of-use drug packaging of medications on compliance among elderly outpatients treated with complex medication regimens. DESIGN: Nonblind, randomized, clinical trial. SETTING: Geriatric outreach health centers in urban public housing units for independent-living elderly people. PATIENTS: Thirty-one patients (aged ≥60 y), each taking three or more prescribed medications. Patients were randomly assigned to one of three study groups: group 1 (n=12), no change in dosing or packaging; group 2 (n=10), conventional packaging with twice-daily dosing; group 3 (n=9), unit-of-use packaging with twice-daily dosing. INTERVENTION: A unit-of-use package consisting of a two-ounce plastic cup with a snap-on lid containing all medications to be taken at the time of dosing. MAIN OUTCOME MEASURES: Medication compliance was assessed monthly for six months using tablet counts. RESULTS: Medication compliance was significantly better in group 3 (92.6 percent) using unit-of-use packaging compared with either group 1 (79 percent) or group 2 (82.6 percent) (p=0.017). Compliance did not differ between groups 1 and 2. CONCLUSIONS: In this small study of elderly outpatients taking three or more medications, unit-of-use packaging and twice-daily dosing improved medication compliance compared with conventional packaging.

Original languageEnglish
Pages (from-to)616-621
Number of pages6
JournalAnnals of Pharmacotherapy
Volume27
Issue number5
StatePublished - 1993

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Medication Adherence
Product Packaging
Outpatients
Drug Packaging
Public Housing
Independent Living
Geriatrics
Tablets
Plastics
Compliance
Randomized Controlled Trials
Health

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Murray, M. D., Murray, M., Manatunga, A. K., Darnell, J. C., Monsanto, H. A., & LaPlante, S. (1993). Medication compliance in elderly outpatients using twice-daily dosing and unit-of-use packaging. Annals of Pharmacotherapy, 27(5), 616-621.

Medication compliance in elderly outpatients using twice-daily dosing and unit-of-use packaging. / Murray, M. D.; Murray, Michael; Manatunga, A. K.; Darnell, J. C.; Monsanto, H. A.; LaPlante, S.

In: Annals of Pharmacotherapy, Vol. 27, No. 5, 1993, p. 616-621.

Research output: Contribution to journalArticle

Murray, MD, Murray, M, Manatunga, AK, Darnell, JC, Monsanto, HA & LaPlante, S 1993, 'Medication compliance in elderly outpatients using twice-daily dosing and unit-of-use packaging', Annals of Pharmacotherapy, vol. 27, no. 5, pp. 616-621.
Murray, M. D. ; Murray, Michael ; Manatunga, A. K. ; Darnell, J. C. ; Monsanto, H. A. ; LaPlante, S. / Medication compliance in elderly outpatients using twice-daily dosing and unit-of-use packaging. In: Annals of Pharmacotherapy. 1993 ; Vol. 27, No. 5. pp. 616-621.
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