Medications and cognitive impairment (CI) in older African-Americans

Research output: Contribution to journalArticle


Medications may preserve cognitive function in older adults or cause dementia. We assessed the risk of CI from the medications used by 2212 African-Americans (mean age 74 years, range 65 to 100 years) at baseline and at 2 and 5 years using the Community Screening Instrument for Dementia. Generalized estimating equations were used to compute the odds of CI (OR, 95% confidence interval) while controlling for age, gender, and education. Vascular protective drugs, defined as drugs for hypertension, diabetes, and hyperlipidemia, were associated with a reduced risk of CI (0.82, 0.68-0.99) as were second-generation antihistamines (0.23, 0.06-0.94). Drugs with anticholinergic properties were associated with an increased risk of CI (1.64, 1.21-2.22 for orally administered and 3.10, 1.42-6.79 for inhaled drugs), as were CNS depressants (1.58, 1.19-2.08) and H2 antagonists (1.50, 1.10-2.06). We conclude that commonly used medications are associated with CI.

Original languageEnglish (US)
Pages (from-to)P83
JournalClinical Pharmacology and Therapeutics
Issue number2
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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