Medications and cognitive impairment (CI) in older African-Americans

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Abstract

Medications may preserve cognitive function in older adults or cause dementia. We assessed the risk of CI from the medications used by 2212 African-Americans (mean age 74 years, range 65 to 100 years) at baseline and at 2 and 5 years using the Community Screening Instrument for Dementia. Generalized estimating equations were used to compute the odds of CI (OR, 95% confidence interval) while controlling for age, gender, and education. Vascular protective drugs, defined as drugs for hypertension, diabetes, and hyperlipidemia, were associated with a reduced risk of CI (0.82, 0.68-0.99) as were second-generation antihistamines (0.23, 0.06-0.94). Drugs with anticholinergic properties were associated with an increased risk of CI (1.64, 1.21-2.22 for orally administered and 3.10, 1.42-6.79 for inhaled drugs), as were CNS depressants (1.58, 1.19-2.08) and H2 antagonists (1.50, 1.10-2.06). We conclude that commonly used medications are associated with CI.

Original languageEnglish
JournalClinical Pharmacology and Therapeutics
Volume69
Issue number2
StatePublished - 2001

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African Americans
Dementia
Non-Sedating Histamine H1 Antagonists
Central Nervous System Depressants
Pharmaceutical Preparations
Protective Agents
Cholinergic Antagonists
Hyperlipidemias
Cognition
Blood Vessels
Confidence Intervals
Hypertension
Education
Cognitive Dysfunction

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "Medications and cognitive impairment (CI) in older African-Americans",
abstract = "Medications may preserve cognitive function in older adults or cause dementia. We assessed the risk of CI from the medications used by 2212 African-Americans (mean age 74 years, range 65 to 100 years) at baseline and at 2 and 5 years using the Community Screening Instrument for Dementia. Generalized estimating equations were used to compute the odds of CI (OR, 95{\%} confidence interval) while controlling for age, gender, and education. Vascular protective drugs, defined as drugs for hypertension, diabetes, and hyperlipidemia, were associated with a reduced risk of CI (0.82, 0.68-0.99) as were second-generation antihistamines (0.23, 0.06-0.94). Drugs with anticholinergic properties were associated with an increased risk of CI (1.64, 1.21-2.22 for orally administered and 3.10, 1.42-6.79 for inhaled drugs), as were CNS depressants (1.58, 1.19-2.08) and H2 antagonists (1.50, 1.10-2.06). We conclude that commonly used medications are associated with CI.",
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T1 - Medications and cognitive impairment (CI) in older African-Americans

AU - Murray, Michael

AU - Lane, K. A.

AU - Gao, Sujuan

AU - Hall, Kathleen

AU - Hendrie, Hugh

PY - 2001

Y1 - 2001

N2 - Medications may preserve cognitive function in older adults or cause dementia. We assessed the risk of CI from the medications used by 2212 African-Americans (mean age 74 years, range 65 to 100 years) at baseline and at 2 and 5 years using the Community Screening Instrument for Dementia. Generalized estimating equations were used to compute the odds of CI (OR, 95% confidence interval) while controlling for age, gender, and education. Vascular protective drugs, defined as drugs for hypertension, diabetes, and hyperlipidemia, were associated with a reduced risk of CI (0.82, 0.68-0.99) as were second-generation antihistamines (0.23, 0.06-0.94). Drugs with anticholinergic properties were associated with an increased risk of CI (1.64, 1.21-2.22 for orally administered and 3.10, 1.42-6.79 for inhaled drugs), as were CNS depressants (1.58, 1.19-2.08) and H2 antagonists (1.50, 1.10-2.06). We conclude that commonly used medications are associated with CI.

AB - Medications may preserve cognitive function in older adults or cause dementia. We assessed the risk of CI from the medications used by 2212 African-Americans (mean age 74 years, range 65 to 100 years) at baseline and at 2 and 5 years using the Community Screening Instrument for Dementia. Generalized estimating equations were used to compute the odds of CI (OR, 95% confidence interval) while controlling for age, gender, and education. Vascular protective drugs, defined as drugs for hypertension, diabetes, and hyperlipidemia, were associated with a reduced risk of CI (0.82, 0.68-0.99) as were second-generation antihistamines (0.23, 0.06-0.94). Drugs with anticholinergic properties were associated with an increased risk of CI (1.64, 1.21-2.22 for orally administered and 3.10, 1.42-6.79 for inhaled drugs), as were CNS depressants (1.58, 1.19-2.08) and H2 antagonists (1.50, 1.10-2.06). We conclude that commonly used medications are associated with CI.

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