Membrane binding and subcellular targeting of C2 domains

Wonhwa Cho, Robert Stahelin

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

C2 domains are a ubiquitous structural module and many of them function in Ca2+-dependent membrane binding and thereby serve as Ca2+ effectors for divergent Ca2+-mediated cellular processes. Extensive structural, biochemical, biophysical, and cellular studies of C2 domains and host proteins in the past decade have shown that due to their structural diversity C2 domains have disparate Ca2+ sensitivity, lipid selectivity and membrane binding mechanisms. This review summarizes the basic structural and functional properties of C2 domains as well as recent findings on Ca2+ and membrane binding, lipid selectivity, and subcellular localization of C2 domains and their host proteins.

Original languageEnglish (US)
Pages (from-to)838-849
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1761
Issue number8
DOIs
StatePublished - Aug 2006
Externally publishedYes

Fingerprint

Membranes
Membrane Lipids
Proteins
C2 Domains

Keywords

  • C2 domain
  • Calcium
  • Lipid
  • Membrane
  • Membrane trafficking
  • Signaling
  • Subcellular localization

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Biophysics

Cite this

Membrane binding and subcellular targeting of C2 domains. / Cho, Wonhwa; Stahelin, Robert.

In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1761, No. 8, 08.2006, p. 838-849.

Research output: Contribution to journalArticle

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