Memory deficits before and after temporal lobectomy: Effect of laterality and age of onset

Andrew J. Saykin, Ruben C. Gur, Neil M. Sussman, Michael J. O'Connor, Raquel E. Gur

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Laterality and age of onset effects on semantic and figural memory were evaluated in 30 right-handed, left speech dominant (amobarbital test) patients with epilepsy before and after temporal lobectomy. There were no effects of focus on WAIS-R IQ scores. Early onset (≤5 years) was associated with lower IQ and memory (WMS). Left Temporal (LT) patients showed worse semantic than figural memory preoperatively. Unexpectedly, early onset LT had marked postoperative decline of figural memory, whereas late onset LT patients showed the previously reported worsening of semantic memory. Right Temporal (RT) lobectomy patients, in contrast, improved in both semantic and figural memory regardless of age of onset. A "crowding effect" was suggested by the decline in figural memory following surgery in the early onset LT patients who remained stable or improved in semantic memory. Results indicate the need to incorporate age of onset of seizures into laterality models of memory function following unilateral temporal-hippocampal resection.

Original languageEnglish (US)
Pages (from-to)191-200
Number of pages10
JournalBrain and Cognition
Volume9
Issue number2
DOIs
StatePublished - Mar 1989

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Memory Disorders
Age of Onset
Semantics
Amobarbital
Onset
Laterality
Crowding
Epilepsy
Seizures

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

Cite this

Memory deficits before and after temporal lobectomy : Effect of laterality and age of onset. / Saykin, Andrew J.; Gur, Ruben C.; Sussman, Neil M.; O'Connor, Michael J.; Gur, Raquel E.

In: Brain and Cognition, Vol. 9, No. 2, 03.1989, p. 191-200.

Research output: Contribution to journalArticle

Saykin, Andrew J. ; Gur, Ruben C. ; Sussman, Neil M. ; O'Connor, Michael J. ; Gur, Raquel E. / Memory deficits before and after temporal lobectomy : Effect of laterality and age of onset. In: Brain and Cognition. 1989 ; Vol. 9, No. 2. pp. 191-200.
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