Men are more susceptible than women to pustule formation in the experimental model of Haemophilus ducreyi infection

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Naturally occurring chancroid is usually more prevalent in men than in women. Goal: To examine whether there were gender differences in susceptibility to Haemophilus ducreyi infection by analyzing the papule and pustule formation rates for men and women who were experimentally inoculated with Haemophilus ducreyi. Study Design: Ninety volunteers were included in the analysis. A total of 189 sites were available for estimation of the papule formation rate, and 166 sites for estimation of the pustule formation rates using logistic regression modeling. Results: Although there were no gender differences in papule formation rates, the women had significantly lower rates of pustule formation than the men after adjustment for the estimated delivered dose. Conclusions: In women the disease will resolve and not progress to the pustular stage of disease as often as in men. The high male-to-female ratio in naturally occurring chancroid may in part reflect biological differences in gender susceptibility to disease progression, although the mechanisms responsible for this difference are unclear.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalSexually Transmitted Diseases
Volume29
Issue number2
StatePublished - 2002
Externally publishedYes

Fingerprint

Haemophilus ducreyi
Haemophilus Infections
Theoretical Models
Chancroid
Disease Progression
Volunteers
Logistic Models

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

Cite this

@article{843b76fed5774f319d0c979172c0b6b9,
title = "Men are more susceptible than women to pustule formation in the experimental model of Haemophilus ducreyi infection",
abstract = "Background: Naturally occurring chancroid is usually more prevalent in men than in women. Goal: To examine whether there were gender differences in susceptibility to Haemophilus ducreyi infection by analyzing the papule and pustule formation rates for men and women who were experimentally inoculated with Haemophilus ducreyi. Study Design: Ninety volunteers were included in the analysis. A total of 189 sites were available for estimation of the papule formation rate, and 166 sites for estimation of the pustule formation rates using logistic regression modeling. Results: Although there were no gender differences in papule formation rates, the women had significantly lower rates of pustule formation than the men after adjustment for the estimated delivered dose. Conclusions: In women the disease will resolve and not progress to the pustular stage of disease as often as in men. The high male-to-female ratio in naturally occurring chancroid may in part reflect biological differences in gender susceptibility to disease progression, although the mechanisms responsible for this difference are unclear.",
author = "Bong, {Cliffton T H} and Jaroslaw Harezlak and Barry Katz and Stanley Spinola",
year = "2002",
language = "English (US)",
volume = "29",
pages = "114--118",
journal = "Sexually Transmitted Diseases",
issn = "0148-5717",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Men are more susceptible than women to pustule formation in the experimental model of Haemophilus ducreyi infection

AU - Bong, Cliffton T H

AU - Harezlak, Jaroslaw

AU - Katz, Barry

AU - Spinola, Stanley

PY - 2002

Y1 - 2002

N2 - Background: Naturally occurring chancroid is usually more prevalent in men than in women. Goal: To examine whether there were gender differences in susceptibility to Haemophilus ducreyi infection by analyzing the papule and pustule formation rates for men and women who were experimentally inoculated with Haemophilus ducreyi. Study Design: Ninety volunteers were included in the analysis. A total of 189 sites were available for estimation of the papule formation rate, and 166 sites for estimation of the pustule formation rates using logistic regression modeling. Results: Although there were no gender differences in papule formation rates, the women had significantly lower rates of pustule formation than the men after adjustment for the estimated delivered dose. Conclusions: In women the disease will resolve and not progress to the pustular stage of disease as often as in men. The high male-to-female ratio in naturally occurring chancroid may in part reflect biological differences in gender susceptibility to disease progression, although the mechanisms responsible for this difference are unclear.

AB - Background: Naturally occurring chancroid is usually more prevalent in men than in women. Goal: To examine whether there were gender differences in susceptibility to Haemophilus ducreyi infection by analyzing the papule and pustule formation rates for men and women who were experimentally inoculated with Haemophilus ducreyi. Study Design: Ninety volunteers were included in the analysis. A total of 189 sites were available for estimation of the papule formation rate, and 166 sites for estimation of the pustule formation rates using logistic regression modeling. Results: Although there were no gender differences in papule formation rates, the women had significantly lower rates of pustule formation than the men after adjustment for the estimated delivered dose. Conclusions: In women the disease will resolve and not progress to the pustular stage of disease as often as in men. The high male-to-female ratio in naturally occurring chancroid may in part reflect biological differences in gender susceptibility to disease progression, although the mechanisms responsible for this difference are unclear.

UR - http://www.scopus.com/inward/record.url?scp=0036168504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036168504&partnerID=8YFLogxK

M3 - Article

C2 - 11818898

AN - SCOPUS:0036168504

VL - 29

SP - 114

EP - 118

JO - Sexually Transmitted Diseases

JF - Sexually Transmitted Diseases

SN - 0148-5717

IS - 2

ER -