Meningioma: Current treatment options and future directions

Kevin P. McMullen, Volker W. Stieber

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Benign meningiomas can be observed if not symptomatic or growing. When treatment is indicated, the options are surgery, radiosurgery, fractionated radiation therapy, or a combination of these modalities. Except in certain cases, such as large tumors that require debulking for relief of symptoms, we do not recommend the routine use of combination therapy. Intracranial meningiomas have usually been treated with surgical resection with an expected durable local control of 80% to 90% when a gross total resection (GTR) is obtained. Patients who have inoperable disease, refuse surgery, undergo less than a GTR, or who have aggressive histology should instead be considered candidates for radiation therapy or radiosurgery. White benign meningiomas can be successfully treated definitively or postoperatively with either fractionated radiation therapy or single fraction radiosurgery, atypical or malignant lesions are best treated with fractionated radiation therapy with conventional dosimetric margins. The role of systemic therapy is not yet defined, but multiple agents are being investigated in early phase trials for patients with recurrent or progressive disease after standard therapy has failed.

Original languageEnglish (US)
Pages (from-to)499-509
Number of pages11
JournalCurrent Treatment Options in Oncology
Volume5
Issue number6
StatePublished - Dec 2004
Externally publishedYes

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Meningioma
Radiosurgery
Radiotherapy
Therapeutics
Histology
Direction compound
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Meningioma : Current treatment options and future directions. / McMullen, Kevin P.; Stieber, Volker W.

In: Current Treatment Options in Oncology, Vol. 5, No. 6, 12.2004, p. 499-509.

Research output: Contribution to journalArticle

McMullen, KP & Stieber, VW 2004, 'Meningioma: Current treatment options and future directions', Current Treatment Options in Oncology, vol. 5, no. 6, pp. 499-509.
McMullen, Kevin P. ; Stieber, Volker W. / Meningioma : Current treatment options and future directions. In: Current Treatment Options in Oncology. 2004 ; Vol. 5, No. 6. pp. 499-509.
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