Mesial temporal sclerosis after status epilepticus due to milk alkali syndrome

Eric Dinnerstein, Brenna C. McDonald, Howard B. Cleavinger, Vijay M. Thadani, Barbara C. Jobst

Research output: Contribution to journalArticle

6 Scopus citations


Seizures induced by hypercalcemia are rare. A few case reports of seizures associated with hypercalcemia have been published, but none due to the milk alkali syndrome. This is the first report regarding seizures associated with calcium carbonate overuse. The two patients described in this article, who had no risk factors for developing epilepsy, suffered from status epilepticus probably induced by hypercalcemia. Subsequently, they both developed complex partial seizures, and were later found to have mesial temporal sclerosis on MRI. There are no reports linking hypercalcemia to mesial temporal sclerosis. While this may be a coincidence, there is reason to suspect that the development of persistent epilepsy, possibly due to mesial temporal sclerosis, was caused by prolonged seizures induced by hypercalcemia.

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
Issue number3
StatePublished - Apr 1 2008
Externally publishedYes


  • Hypercalcemia
  • Mesial temporal sclerosis
  • Milk alkali syndrome
  • Status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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