Metabolic alterations in renal and prostate cancer

Chiara Ciccarese, Matteo Santoni, Francesco Massari, Alessandra Modena, Francesco Piva, Alessandro Conti, Roberta Mazzucchelli, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Giampaolo Tortora, Rodolfo Montironi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: Cancer metabolism is emerging as a promising research area in genitourinary tumors. Both renal cell carcinoma (RCC) and prostate cancer (PCa) cells exhibit marked alterations of their metabolism. These changes include increased aerobic glycolysis (the Warburg effect), increased protein and DNA synthesis and de novo fatty acid (FA) synthesis. Objective: Understanding the molecular mechanisms underlying such alterations will represent a major step forward in cancer research. Indeed, reprogramming cancer cell energy metabolism represents a promising hallmark of cancer and may pave the way for novel personalized approaches. Method: PubMed databases were searched for articles published about cancer metabolism in genitourinary tumors. Results and Conclusion: This review is focused on the metabolic alterations that occur in RCC and PCa and describes the mechanisms underlying such metabolic changes.

Original languageEnglish (US)
Pages (from-to)150-155
Number of pages6
JournalCurrent Drug Metabolism
Volume17
Issue number2
StatePublished - Feb 1 2016

Keywords

  • Cancer metabolism
  • Glycolysis
  • Lipogenesis
  • Prostate cancer
  • Renal cell carcinoma
  • Warburg effect

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

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  • Cite this

    Ciccarese, C., Santoni, M., Massari, F., Modena, A., Piva, F., Conti, A., Mazzucchelli, R., Cheng, L., Lopez-Beltran, A., Scarpelli, M., Tortora, G., & Montironi, R. (2016). Metabolic alterations in renal and prostate cancer. Current Drug Metabolism, 17(2), 150-155.