Metabolic alterations in renal cell carcinoma

Francesco Massari, Chiara Ciccarese, Matteo Santoni, Matteo Brunelli, Francesco Piva, Alessandra Modena, Davide Bimbatti, Emanuela Fantinel, Daniele Santini, Liang Cheng, Stefano Cascinu, Rodolfo Montironi, Giampaolo Tortora

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Renal cell carcinoma (RCC) is a metabolic disease, being characterized by the dysregulation of metabolic pathways involved in oxygen sensing (VHL/HIF pathway alterations and the subsequent up-regulation of HIF-responsive genes such as VEGF, PDGF, EGF, and glucose transporters GLUT1 and GLUT4, which justify the RCC reliance on aerobic glycolysis), energy sensing (fumarate hydratase-deficient, succinate dehydrogenase-deficient RCC, mutations of HGF/MET pathway resulting in the metabolic Warburg shift marked by RCC increased dependence on aerobic glycolysis and the pentose phosphate shunt, augmented lipogenesis, and reduced AMPK and Krebs cycle activity) and/or nutrient sensing cascade (deregulation of AMPK-TSC1/2-mTOR and PI3K-Akt-mTOR pathways). We analyzed the key metabolic abnormalities underlying RCC carcinogenesis, highlighting those altered pathways that may represent potential targets for the development of more effective therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)767-776
Number of pages10
JournalCancer Treatment Reviews
Volume41
Issue number9
DOIs
StatePublished - Nov 2015

Keywords

  • Metabolic pathways
  • RCC carcinogenesis
  • Renal cell carcinoma
  • Therapeutic strategies

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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    Massari, F., Ciccarese, C., Santoni, M., Brunelli, M., Piva, F., Modena, A., Bimbatti, D., Fantinel, E., Santini, D., Cheng, L., Cascinu, S., Montironi, R., & Tortora, G. (2015). Metabolic alterations in renal cell carcinoma. Cancer Treatment Reviews, 41(9), 767-776. https://doi.org/10.1016/j.ctrv.2015.07.002