Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats

M. C. Yoder, J. M. Egler, M. Yudkoff, J. Chatten, S. D. Douglas, R. A. Polin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The administration of sublethal doses of Escherichia coli O111:B4 endotoxin to starved rats results in significant increases in plasma ammonia, free fatty acids, and serum lactate compared with starved controls. These metabolic alterations are associated with Reye syndrome-like histological findings of hepatic microvesicular fatty accumulation and hepatic ultrastructural evidence of mitochondrial pleomorphism with matrix disruption. This sublethal endotoxin model may help elucidate the relationship between the hepatic mitochondrial injury, characteristic metabolic impairment, and encephalopathy seen in patients with Reye syndrome.

Original languageEnglish (US)
Pages (from-to)329-331
Number of pages3
JournalInfection and immunity
Volume47
Issue number1
StatePublished - Mar 13 1985

Fingerprint

Reye Syndrome
Endotoxins
Liver
Metabolic Brain Diseases
Ammonia
Nonesterified Fatty Acids
Lactic Acid
Escherichia coli
Wounds and Injuries
Serum

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Yoder, M. C., Egler, J. M., Yudkoff, M., Chatten, J., Douglas, S. D., & Polin, R. A. (1985). Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats. Infection and immunity, 47(1), 329-331.

Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats. / Yoder, M. C.; Egler, J. M.; Yudkoff, M.; Chatten, J.; Douglas, S. D.; Polin, R. A.

In: Infection and immunity, Vol. 47, No. 1, 13.03.1985, p. 329-331.

Research output: Contribution to journalArticle

Yoder, MC, Egler, JM, Yudkoff, M, Chatten, J, Douglas, SD & Polin, RA 1985, 'Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats', Infection and immunity, vol. 47, no. 1, pp. 329-331.
Yoder, M. C. ; Egler, J. M. ; Yudkoff, M. ; Chatten, J. ; Douglas, S. D. ; Polin, R. A. / Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats. In: Infection and immunity. 1985 ; Vol. 47, No. 1. pp. 329-331.
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