Bone is a metabolically sensitive organ that produces structural proteins, stores minerals and catabolizes proteins, under both autocrine and paracrine influences. It produces hormones [e.g. fibroblast growth factor 23 (FGF-23)] that control its turnover and mineral metabolism, and is acted upon by hormones produced in other glands and organs in the body [e.g. parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D]. When systemic mineral or skeletal metabolism becomes unbalanced or dysregulated, the resulting skeletal disease can cause a range of complications, including pain and discomfort, fracture, or even death. This chapter describes some common and uncommon conditions, including osteoporosis, osteogenesis imperfecta, hyper- and hypoparathyroidism, rickets/osteomalacia, hypo- and hyperphosphatemia, hypophosphatasia, Paget disease, and osteopetrosis. These examples are used to illustrate the broader concepts associated with abnormalities in mineral metabolism, collagen defects, and bone remodeling as they relate to skeletal health and function.
|Original language||English (US)|
|Title of host publication||Basic and Applied Bone Biology|
|Number of pages||28|
|State||Published - Aug 12 2013|
- Osteogenesis imperfecta
- Paget disease
ASJC Scopus subject areas