Metabolic Bone Diseases

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Bone is a metabolically sensitive organ that produces structural proteins, stores minerals and catabolizes proteins, under both autocrine and paracrine influences. It produces hormones [e.g. fibroblast growth factor 23 (FGF-23)] that control its turnover and mineral metabolism, and is acted upon by hormones produced in other glands and organs in the body [e.g. parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D]. When systemic mineral or skeletal metabolism becomes unbalanced or dysregulated, the resulting skeletal disease can cause a range of complications, including pain and discomfort, fracture, or even death. This chapter describes some common and uncommon conditions, including osteoporosis, osteogenesis imperfecta, hyper- and hypoparathyroidism, rickets/osteomalacia, hypo- and hyperphosphatemia, hypophosphatasia, Paget disease, and osteopetrosis. These examples are used to illustrate the broader concepts associated with abnormalities in mineral metabolism, collagen defects, and bone remodeling as they relate to skeletal health and function.

Original languageEnglish (US)
Title of host publicationBasic and Applied Bone Biology
PublisherElsevier Inc.
Pages317-344
Number of pages28
ISBN (Print)9780124160156
DOIs
StatePublished - Aug 12 2013

Keywords

  • Osteogenesis imperfecta
  • Osteomalacia
  • Osteopetrosis
  • Osteoporosis
  • Paget disease
  • Parathyroid
  • Phosphate
  • Rickets

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

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    Imel, E. A., DiMeglio, L. A., & Burr, D. B. (2013). Metabolic Bone Diseases. In Basic and Applied Bone Biology (pp. 317-344). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-416015-6.00016-2