Metabolic Effects of Dichloroacetate

D. W. Crabb, R. A. Harris, David Stansbie, Richard J. Sherriff

Research output: Contribution to journalLetter

3 Scopus citations


To the Editor: We read with interest the report of Stacpoole et al. in the March 9 issue of the Journal concerning human trials with dichloroacetate. Some observations that we have made are of potential importance for further experimentation. Dichloroacetate stimulates fatty acid synthesis at 1 to 2 mM in isolated rat-liver cells, but this stimulation is lost at higher concentrations.1 Provided physiologic concentrations of bicarbonate, as well as a source of amino groups for the malate-asparate shuttle, are available, dichloroacetate does not inhibit gluconeogenesis at concentrations that fully activate pyruvate dehydrogenase.2 It is unfortunate that little work correlating blood.

Original languageEnglish (US)
Pages (from-to)255-256
Number of pages2
JournalNew England Journal of Medicine
Issue number5
StatePublished - Aug 3 1978

ASJC Scopus subject areas

  • Medicine(all)

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