Metabolic effects of proglycosyn

Kunio Yamanouchi, Thomas W. Stephens, Kiwami Chikada, Samuel J. Dominianni, Heidi Behforouz, Peter Scislowski, Anna DePaoli-Roach, David W. Allmann, Robert A. Harris

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Proglycosyn, a phenylacyl imidazolium compound that lowers blood glucose levels, was demonstrated previously to promote hepatic glycogen synthesis, stabilize hepatic glycogen stores, activate glycogen synthase, inactivate glycogen phosphorylase, and inhibit glycolysis. In the present study proglycosyn was found to inhibit fatty acid synthesis, stimulate fatty acid oxidation, and lower fructose 2,6-bisphosphate levels, but to have no significant effects on cell swelling and the levels of cAMP in hepatocytes prepared from fed rats. Verapamil and atropine blocked the effects of proglycosyn on glycogen metabolism, but these compounds inhibit proglycosyn accumulation by hepatocytes. Proglycosyn stimulated phosphoprotein phosphatase activity in postmitochondrial extracts, as measured by dephosphorylation of phosphorylase a and glycogen synthase D, but this action required a very high concentration of the compound, making it unlikely to be the actual mechanism involved. It is proposed that a metabolite of proglycosyn is responsible for its metabolic effects.

Original languageEnglish (US)
Pages (from-to)609-615
Number of pages7
JournalArchives of Biochemistry and Biophysics
Volume294
Issue number2
DOIs
StatePublished - May 1 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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    Yamanouchi, K., Stephens, T. W., Chikada, K., Dominianni, S. J., Behforouz, H., Scislowski, P., DePaoli-Roach, A., Allmann, D. W., & Harris, R. A. (1992). Metabolic effects of proglycosyn. Archives of Biochemistry and Biophysics, 294(2), 609-615. https://doi.org/10.1016/0003-9861(92)90732-C