Metabolic Regulation

M. S. Patel, R. A. Harris

Research output: Chapter in Book/Report/Conference proceedingChapter


The principles of metabolic regulation are described in the context of the major metabolic pathways of the liver. In the fed state, increased plasma insulin initiates a signaling cascade that enhances flux through pathways that promote glycogen and triacylglycerol synthesis. This is achieved by well-coordinated regulation of key enzymes by allosteric effectors, covalent modification, inhibitory protein interaction, and altered gene expression. In the fasting state, increased plasma glucagon activates a signaling cascade that enhances glycogenolysis, gluconeogenesis, and ketogenesis. Regulation of key enzymes plays a central role in enhancing the flux in the metabolic pathways to maintain energy homeostasis and glucose homeostasis.

Original languageEnglish (US)
Title of host publicationMolecular Cell Biology
PublisherElsevier Inc.
Number of pages10
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
StatePublished - Jan 1 2016


  • Allosteric regulation
  • Covalent modification
  • Energy homeostasis
  • Glucose homeostasis
  • Glycogen metabolism
  • Glycolysis
  • Hormonal action
  • Lipogenesis
  • Metabolic pathways
  • Regulation of metabolism
  • Transcriptional control

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Patel, M. S., & Harris, R. A. (2016). Metabolic Regulation. In Molecular Cell Biology (Vol. 1, pp. 288-297). Elsevier Inc..