Metabolic Regulation

M. S. Patel, R. A. Harris

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The principles of metabolic regulation are described in the context of the major metabolic pathways of the liver. In the fed state, increased plasma insulin initiates a signaling cascade that enhances flux through pathways that promote glycogen and triacylglycerol synthesis. This is achieved by well-coordinated regulation of key enzymes by allosteric effectors, covalent modification, inhibitory protein interaction, and altered gene expression. In the fasting state, increased plasma glucagon activates a signaling cascade that enhances glycogenolysis, gluconeogenesis, and ketogenesis. Regulation of key enzymes plays a central role in enhancing the flux in the metabolic pathways to maintain energy homeostasis and glucose homeostasis.

Original languageEnglish (US)
Title of host publicationMolecular Cell Biology
PublisherElsevier Inc.
Pages288-297
Number of pages10
Volume1
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
StatePublished - Jan 1 2016

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Keywords

  • Allosteric regulation
  • Covalent modification
  • Energy homeostasis
  • Glucose homeostasis
  • Glycogen metabolism
  • Glycolysis
  • Hormonal action
  • Lipogenesis
  • Metabolic pathways
  • Regulation of metabolism
  • Transcriptional control

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Patel, M. S., & Harris, R. A. (2016). Metabolic Regulation. In Molecular Cell Biology (Vol. 1, pp. 288-297). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-394447-4.10034-3