Metabolism of 13-hydroxy-9,11-octadecadienoic acid by MOLT-4 lymphocytes

Christos Hadjiagapiou, Jeffrey Travers, Richard Fertel, Howard Sprecher

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

MOLT-4 lymphocytes metabolize 13-hydroxy-9,11-octadecadienoic acid, via the β-oxidation pathway with retention of the ω6 hydroxyl group and the conjugated diene system. The products which accumulate include 11-hydroxy-7,9-hexadecadienoic acid and 9-hydroxy-5,7-tetradecadienoic acid. In addition, it was possible to isolate two β-hydroxy acids which were shown to be 3,13-dihydroxy-9,11-octadecadienoic acid and 3,11-dihydroxy-7,9-hexadecadienoic acid. The odd chain aldehyde, 12-hydroxy-8,10-heptadecadien-1-al, also was detected. However, neither the pathway nor the immediate precursor for the synthesis of this compound was established.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume1046
Issue number2
DOIs
StatePublished - Sep 18 1990
Externally publishedYes

Fingerprint

Hydroxy Acids
Lymphocytes
Metabolism
Acids
Aldehydes
Hydroxyl Radical
Oxidation
13-hydroxy-9,11-octadecadienoic acid
9,11-linoleic acid

Keywords

  • (Lymphocyte)
  • Beta oxidation
  • Hydroxy acid
  • Lipoxygenase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Endocrinology

Cite this

Metabolism of 13-hydroxy-9,11-octadecadienoic acid by MOLT-4 lymphocytes. / Hadjiagapiou, Christos; Travers, Jeffrey; Fertel, Richard; Sprecher, Howard.

In: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, Vol. 1046, No. 2, 18.09.1990, p. 167-172.

Research output: Contribution to journalArticle

Hadjiagapiou, Christos ; Travers, Jeffrey ; Fertel, Richard ; Sprecher, Howard. / Metabolism of 13-hydroxy-9,11-octadecadienoic acid by MOLT-4 lymphocytes. In: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism. 1990 ; Vol. 1046, No. 2. pp. 167-172.
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