Metabolism of 13-hydroxy-9,11-octadecadienoic acid by MOLT-4 lymphocytes

Christos Hadjiagapiou, Jeffrey Travers, Richard Fertel, Howard Sprecher

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

MOLT-4 lymphocytes metabolize 13-hydroxy-9,11-octadecadienoic acid, via the β-oxidation pathway with retention of the ω6 hydroxyl group and the conjugated diene system. The products which accumulate include 11-hydroxy-7,9-hexadecadienoic acid and 9-hydroxy-5,7-tetradecadienoic acid. In addition, it was possible to isolate two β-hydroxy acids which were shown to be 3,13-dihydroxy-9,11-octadecadienoic acid and 3,11-dihydroxy-7,9-hexadecadienoic acid. The odd chain aldehyde, 12-hydroxy-8,10-heptadecadien-1-al, also was detected. However, neither the pathway nor the immediate precursor for the synthesis of this compound was established.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume1046
Issue number2
DOIs
StatePublished - Sep 18 1990
Externally publishedYes

Keywords

  • (Lymphocyte)
  • Beta oxidation
  • Hydroxy acid
  • Lipoxygenase

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Endocrinology

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