Metallopanstimulin is overexpressed in a patient with colonic carcinoma

Daniel R. Ganger, Paul D. Hamilton, James Fletcher, J. Albert Fernandez-Pol

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Human metallopanstimulin (MPS-1) is a 9.4-kDa multifunctional ribosomal S27 / nuclear 'zinc finger' protein which is expressed in a wide variety of actively proliferating cells and tumor tissues. In this paper, we present a case of overexpression of MPS-1 in colon cancer tissues of a seventeen year old male. Methods: Biopsies at the anastomosis and adjacent normal colonic mucosa were obtained by colonoscopy twelve months after right hemicolectomy for an ascending colon well differentiated adenocarcinoma. Immunohistochemical localization of MPS-1 protein was performed by using specific anti-MPS-1 antibodies directed against the N-terminal region of this protein. Results: Immunohistochemistry demostrated an overexpression of MPS-1 in colonic mucosa crypts in the samples obtained at the anastomosis. In contrast, no expression of MPS-1 was observed in the adjacent normal mucosa. Histopathology performed with hematoxilin and eosin staining revealed focal crypt distortion and proliferation, but no carcinoma. Conclusions: In this case, the overexpression of MPS-1 was a more definitive evidence of malignant transformation than histology, as demonstrated by the clinical course of the disease. The results support the hypothesis that increased levels of tissue MPS-1 may correlate with a more aggressive behavior of colon malignancy.

Original languageEnglish (US)
Pages (from-to)1993-1999
Number of pages7
JournalAnticancer Research
Volume17
Issue number3 C
StatePublished - 1997
Externally publishedYes

Fingerprint

Mucous Membrane
Carcinoma
Ascending Colon
Proteins
Zinc Fingers
Colonoscopy
Eosine Yellowish-(YS)
Colonic Neoplasms
Neoplasms
Histology
Colon
Adenocarcinoma
Immunohistochemistry
Staining and Labeling
Biopsy
Antibodies

Keywords

  • Colon cancer
  • Metallopanstimulin
  • Ribosomal S27 protein
  • Tumor markers
  • Zinc finger proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ganger, D. R., Hamilton, P. D., Fletcher, J., & Albert Fernandez-Pol, J. (1997). Metallopanstimulin is overexpressed in a patient with colonic carcinoma. Anticancer Research, 17(3 C), 1993-1999.

Metallopanstimulin is overexpressed in a patient with colonic carcinoma. / Ganger, Daniel R.; Hamilton, Paul D.; Fletcher, James; Albert Fernandez-Pol, J.

In: Anticancer Research, Vol. 17, No. 3 C, 1997, p. 1993-1999.

Research output: Contribution to journalArticle

Ganger, DR, Hamilton, PD, Fletcher, J & Albert Fernandez-Pol, J 1997, 'Metallopanstimulin is overexpressed in a patient with colonic carcinoma', Anticancer Research, vol. 17, no. 3 C, pp. 1993-1999.
Ganger DR, Hamilton PD, Fletcher J, Albert Fernandez-Pol J. Metallopanstimulin is overexpressed in a patient with colonic carcinoma. Anticancer Research. 1997;17(3 C):1993-1999.
Ganger, Daniel R. ; Hamilton, Paul D. ; Fletcher, James ; Albert Fernandez-Pol, J. / Metallopanstimulin is overexpressed in a patient with colonic carcinoma. In: Anticancer Research. 1997 ; Vol. 17, No. 3 C. pp. 1993-1999.
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