Metastatic esophageal carcinoma masquerading as inflammatory breast carcinoma

Christy L. Nebesio, Robert J. Goulet, Paul Helft, Steven D. Billings

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 50-year-old Caucasian woman with a history of esophageal adenocarcinoma presented with a 3-week history of right breast swelling and progressive erythema. Twenty-two months prior to presentation, she had been diagnosed with adenocarcinoma of the esophagus (T3,N1,M1a) and underwent neoadjuvant chemoradiotherapy followed by surgical resection. On physical examination, the right breast was red, swollen (40% larger than the contralateral breast), tender to palpation, and warm to the touch (Fig. 1). No mass was palpable. On the basis of the clinical findings, inflammatory breast carcinoma was suspected. A punch biopsy revealed a poorly differentiated adenocarcinoma with extensive involvement of dermal lymphatics (Fig. 2). The clinical and histologic differential diagnosis included inflammatory breast carcinoma vs. metastatic esophageal adenocarcinoma to the skin of the breast. To resolve this question, immunohistochemical stains for estrogen and progesterone receptors and CDX-2 (BioGenex, San Ramon, CA, USA) were performed. CDX-2 is an intestinal homeobox gene expressed in gastrointestinal epithelium and gastrointestinal tumors. The tumor nuclei were positive for CDX-2 but negative for both steroid receptors (Fig. 3), confirming the diagnosis of metastatic esophageal adenocarcinoma.

Original languageEnglish
Pages (from-to)303-305
Number of pages3
JournalInternational Journal of Dermatology
Volume46
Issue number3
DOIs
StatePublished - Mar 2007

Fingerprint

Inflammatory Breast Neoplasms
Adenocarcinoma
Breast
Carcinoma
Skin
Steroid Receptors
Homeobox Genes
Palpation
Touch
Chemoradiotherapy
Progesterone Receptors
Erythema
Estrogen Receptors
Physical Examination
Neoplasms
Differential Diagnosis
Coloring Agents
Epithelium
Biopsy

ASJC Scopus subject areas

  • Dermatology

Cite this

Metastatic esophageal carcinoma masquerading as inflammatory breast carcinoma. / Nebesio, Christy L.; Goulet, Robert J.; Helft, Paul; Billings, Steven D.

In: International Journal of Dermatology, Vol. 46, No. 3, 03.2007, p. 303-305.

Research output: Contribution to journalArticle

Nebesio, Christy L. ; Goulet, Robert J. ; Helft, Paul ; Billings, Steven D. / Metastatic esophageal carcinoma masquerading as inflammatory breast carcinoma. In: International Journal of Dermatology. 2007 ; Vol. 46, No. 3. pp. 303-305.
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