Metastatic juxtaglomerular cell tumor in a 52-year-old man

Xiuzhen Duan, Patrick Bruneval, Rasheed Hammadeh, Raoul Fresco, John Eble, Joseph I. Clark, Wickii T. Vigneswaran, Robert C. Flanigan, Maria M. Picken

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Juxtaglomerular cell tumor is a rare renal neoplasm arising from the juxtaglomerular apparatus. Approximately 70 cases have been reported in the English literature since it was first described by Robertson et al in 1967. This tumor has been considered benign and resection has so far been curative. In this paper, we report the first metastatic juxtaglomerular cell tumor. The 15-cm tumor occurred in the right kidney of a 46-year-old man. It invaded the renal vein, and was treated by radical nephrectomy in 1995. The diagnosis at that time was renal cell carcinoma. The patient was well for 6 years and then developed bilateral lung masses, which were resected. Microscopically, the tumors from the kidney and the lungs were similar, consisting of solid sheets of uniformly round-to-polygonal cells intermixed with abundant delicate vasculature. Both renal and pulmonary tumors were positive for vimentin, renin, and only focally to CD34. Electron microscopic studies performed on the paraffin-embedded renal tumor and formalin-fixed lung tumor revealed the typical rhomboid crystals of proto-renin. In consideration of the characteristic morphologic features, immunohistochemistry, and the presence of rhomboid crystals of proto-renin, the diagnosis was modified to malignant juxtaglomerular cell tumor.

Original languageEnglish
Pages (from-to)1098-1102
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume28
Issue number8
DOIs
StatePublished - Aug 2004

Fingerprint

Neoplasms
Renin
Kidney
Lung
Juxtaglomerular Apparatus
Literature
Renal Veins
Kidney Neoplasms
Vimentin
Nephrectomy
Renal Cell Carcinoma
Paraffin
Formaldehyde
Immunohistochemistry
Electrons

Keywords

  • Electron microscopy
  • Immunohistochemistry
  • Juxtaglomerular cell tumor
  • Malignant
  • Renin

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Duan, X., Bruneval, P., Hammadeh, R., Fresco, R., Eble, J., Clark, J. I., ... Picken, M. M. (2004). Metastatic juxtaglomerular cell tumor in a 52-year-old man. American Journal of Surgical Pathology, 28(8), 1098-1102. https://doi.org/10.1097/01.pas.0000126722.29212.a7

Metastatic juxtaglomerular cell tumor in a 52-year-old man. / Duan, Xiuzhen; Bruneval, Patrick; Hammadeh, Rasheed; Fresco, Raoul; Eble, John; Clark, Joseph I.; Vigneswaran, Wickii T.; Flanigan, Robert C.; Picken, Maria M.

In: American Journal of Surgical Pathology, Vol. 28, No. 8, 08.2004, p. 1098-1102.

Research output: Contribution to journalArticle

Duan, X, Bruneval, P, Hammadeh, R, Fresco, R, Eble, J, Clark, JI, Vigneswaran, WT, Flanigan, RC & Picken, MM 2004, 'Metastatic juxtaglomerular cell tumor in a 52-year-old man', American Journal of Surgical Pathology, vol. 28, no. 8, pp. 1098-1102. https://doi.org/10.1097/01.pas.0000126722.29212.a7
Duan, Xiuzhen ; Bruneval, Patrick ; Hammadeh, Rasheed ; Fresco, Raoul ; Eble, John ; Clark, Joseph I. ; Vigneswaran, Wickii T. ; Flanigan, Robert C. ; Picken, Maria M. / Metastatic juxtaglomerular cell tumor in a 52-year-old man. In: American Journal of Surgical Pathology. 2004 ; Vol. 28, No. 8. pp. 1098-1102.
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