Metastatic Pancreatic Adenocarcinoma After Total Pancreatectomy Islet Autotransplantation for Chronic Pancreatitis

S. Muratore, X. Zeng, Murray Korc, S. McElyea, J. Wilhelm, M. Bellin, G. Beilman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Total pancreatectomy with islet autotransplantation (TPIAT) is being used increasingly as a definitive treatment for chronic pancreatitis. Patients with chronic pancreatitis have an elevated risk of pancreatic cancer, which can also masquerade as acute or chronic pancreatitis, making the diagnosis challenging. We describe here the first case of pancreatic ductal adenocarcinoma developing in the liver of a patient after TPIAT for presumed benign chronic pancreatitis. Retrospective analysis of the patient's preoperative serum revealed normal carbohydrate antigen 19-9 and carcinoembryonic antigen levels but elevated levels of microRNAs -10b, -30c, and -106b compared with controls. Screening guidelines are important to reduce the risk of transplantation of malignant tissue. More sensitive screening tools, including the potential use of microRNAs, are needed to detect early preclinical disease, given the highly malignant nature of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)2747-2752
Number of pages6
JournalAmerican Journal of Transplantation
Volume16
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Pancreatectomy
Autologous Transplantation
Chronic Pancreatitis
Adenocarcinoma
MicroRNAs
Pancreatic Neoplasms
Tissue Transplantation
Carcinoembryonic Antigen
Carbohydrates
Guidelines
Antigens
Liver
Serum
Therapeutics

Keywords

  • autotransplantation
  • cancer/malignancy/neoplasia
  • cancer/malignancy/neoplasia: metastatic disease
  • clinical research/practice
  • islet transplantation
  • islets of Langerhans

ASJC Scopus subject areas

  • Immunology and Allergy
  • Medicine(all)
  • Pharmacology (medical)
  • Transplantation

Cite this

Metastatic Pancreatic Adenocarcinoma After Total Pancreatectomy Islet Autotransplantation for Chronic Pancreatitis. / Muratore, S.; Zeng, X.; Korc, Murray; McElyea, S.; Wilhelm, J.; Bellin, M.; Beilman, G.

In: American Journal of Transplantation, Vol. 16, No. 9, 01.09.2016, p. 2747-2752.

Research output: Contribution to journalArticle

Muratore, S. ; Zeng, X. ; Korc, Murray ; McElyea, S. ; Wilhelm, J. ; Bellin, M. ; Beilman, G. / Metastatic Pancreatic Adenocarcinoma After Total Pancreatectomy Islet Autotransplantation for Chronic Pancreatitis. In: American Journal of Transplantation. 2016 ; Vol. 16, No. 9. pp. 2747-2752.
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