Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity

Changwei Zhou, Rong Sun, Sujuan Zhuang, Chongyi Sun, Yongqing Jiang, Yang Cui, Shitou Li, Yanqiu Xiao, Yansheng Du, Huiying Gu, Qingpeng Liu

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Metformin, a wildly used drug for type 2 diabetes, has recently been proven to protect a variety of cells from stress including stroke. Glutamate is an excitatory neurotransmitter that contributes to excitatory neuronal damage involved in stroke and neurodegenerative disorders. In this study, we demonstrated that pretreatment of rat cerebellar granule neurons (CGN) with metformin greatly enhanced cell viability against glutamate-induced neurotoxicity. Metformin significantly attenuated neuronal apoptosis in glutamate-treated CGN by reducing cytochrome c releasing, caspase-3 activation and phosphorylation of MAP kinases. Our results suggested that metformin was able to directly inhibit glutamate induced excitotoxicity in neurons and might be beneficial to patients suffered from stroke and neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)241-245
Number of pages5
JournalBrain Research Bulletin
Volume121
DOIs
StatePublished - Mar 1 2016

Keywords

  • Cerebellar granule neurons
  • Excitotoxicity
  • Glutamate
  • MAPK
  • Metformin
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Zhou, C., Sun, R., Zhuang, S., Sun, C., Jiang, Y., Cui, Y., Li, S., Xiao, Y., Du, Y., Gu, H., & Liu, Q. (2016). Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity. Brain Research Bulletin, 121, 241-245. https://doi.org/10.1016/j.brainresbull.2016.02.009