Methamphetamine selectively alters brain glutathione

Christine Harold, Tanya Wallace, Ross Friedman, Gary Gudelsky, Bryan Yamamoto

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

As methamphetamine-induced neurotoxicity has been proposed to involve oxidative stress, reduced and oxidized glutathione (GSH and GSSG, respectively), vitamin E and ascorbate were measured in the striata of rats killed 2 or 24 h after a neurotoxic regimen of methamphetamine. At 2 h, methamphetamine increased GSH and GSSG (32.5% and 43.7%, respectively) compared to controls at 2 h. No difference was seen in glutathione at 24 h, and in vitamin E and ascorbate at either time point. These findings indicate selectivity of methamphetamine for the glutathione system and a role for methamphetamine in inducing oxidative stress. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)99-102
Number of pages4
JournalEuropean Journal of Pharmacology
Volume400
Issue number1
DOIs
StatePublished - Jul 14 2000
Externally publishedYes

Keywords

  • Glutathione
  • Methamphetamine
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology

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