Methods and devices for local drug delivery in coronary and peripheral arteries

Robert L. Wilensky, Keith L. March, Irmina Gradus-Pizlo, Anthony J. Spaedy, David R. Hathaway

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

New developments in catheter design, molecular biology, and polymer chemistry have made it possible to deliver pharmaceutical agents and genetic material directly into the arterial wall to modulate the response to injury. Several local drug delivery catheters of various designs in addition to biodegradable and coated stents are currently being evaluated as devices to facilitate local delivery of agents into the arterial wall. Approaches to locally sustained delivery include the controlled release of medications, the affinity-based delivery of medications administered systemically but accumulated locally, and gene therapy.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalTrends in Cardiovascular Medicine
Volume3
Issue number5
DOIs
StatePublished - 1993

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Coronary Vessels
Catheters
Equipment and Supplies
Pharmaceutical Preparations
Genetic Therapy
Stents
Molecular Biology
Polymers
Wounds and Injuries
Genes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Wilensky, R. L., March, K. L., Gradus-Pizlo, I., Spaedy, A. J., & Hathaway, D. R. (1993). Methods and devices for local drug delivery in coronary and peripheral arteries. Trends in Cardiovascular Medicine, 3(5), 163-170. https://doi.org/10.1016/1050-1738(93)90001-M

Methods and devices for local drug delivery in coronary and peripheral arteries. / Wilensky, Robert L.; March, Keith L.; Gradus-Pizlo, Irmina; Spaedy, Anthony J.; Hathaway, David R.

In: Trends in Cardiovascular Medicine, Vol. 3, No. 5, 1993, p. 163-170.

Research output: Contribution to journalArticle

Wilensky, RL, March, KL, Gradus-Pizlo, I, Spaedy, AJ & Hathaway, DR 1993, 'Methods and devices for local drug delivery in coronary and peripheral arteries', Trends in Cardiovascular Medicine, vol. 3, no. 5, pp. 163-170. https://doi.org/10.1016/1050-1738(93)90001-M
Wilensky, Robert L. ; March, Keith L. ; Gradus-Pizlo, Irmina ; Spaedy, Anthony J. ; Hathaway, David R. / Methods and devices for local drug delivery in coronary and peripheral arteries. In: Trends in Cardiovascular Medicine. 1993 ; Vol. 3, No. 5. pp. 163-170.
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