Mice genetically selected for differences in open-field activity after ethanol

John C. Crabbe, Emmett R. Young, Catherine M. Deutsch, Brenda R. Tam, Ann Kosobud

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.

Original languageEnglish (US)
Pages (from-to)577-581
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume27
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Ethanol
Injections
Population

Keywords

  • Behavioral genetics
  • Selective breeding, Pharmacogenetics, Open-field activity, Ethanol stimulation, Reward, Activity

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Mice genetically selected for differences in open-field activity after ethanol. / Crabbe, John C.; Young, Emmett R.; Deutsch, Catherine M.; Tam, Brenda R.; Kosobud, Ann.

In: Pharmacology Biochemistry and Behavior, Vol. 27, No. 3, 1987, p. 577-581.

Research output: Contribution to journalArticle

Crabbe, John C. ; Young, Emmett R. ; Deutsch, Catherine M. ; Tam, Brenda R. ; Kosobud, Ann. / Mice genetically selected for differences in open-field activity after ethanol. In: Pharmacology Biochemistry and Behavior. 1987 ; Vol. 27, No. 3. pp. 577-581.
@article{debe3ec7623347dfa651bea3fd053d11,
title = "Mice genetically selected for differences in open-field activity after ethanol",
abstract = "Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.",
keywords = "Behavioral genetics, Selective breeding, Pharmacogenetics, Open-field activity, Ethanol stimulation, Reward, Activity",
author = "Crabbe, {John C.} and Young, {Emmett R.} and Deutsch, {Catherine M.} and Tam, {Brenda R.} and Ann Kosobud",
year = "1987",
doi = "10.1016/0091-3057(87)90371-6",
language = "English (US)",
volume = "27",
pages = "577--581",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Mice genetically selected for differences in open-field activity after ethanol

AU - Crabbe, John C.

AU - Young, Emmett R.

AU - Deutsch, Catherine M.

AU - Tam, Brenda R.

AU - Kosobud, Ann

PY - 1987

Y1 - 1987

N2 - Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.

AB - Starting from a population of genetically heterogeneous mice, selective breeding is being used to develop lines differing in sensitivity to ethanol-induced open-field activity. Mice are tested twice for 4 min in an open field. The first test is between min 2-6 after injection of saline. Twenty-four hr later, a similar test is performed after injection of ethanol (1.5 g/kg). Two independent FAST lines are being selected for ethanol-induced increases in activity, and two independent SLOW lines are being selected for ethanol-induced decreases. After four generations of selection, the lines have diverged significantly. These lines should be useful for exploring the neuropharmacological basis for the activating and rewarding properties of ethanol.

KW - Behavioral genetics

KW - Selective breeding, Pharmacogenetics, Open-field activity, Ethanol stimulation, Reward, Activity

UR - http://www.scopus.com/inward/record.url?scp=0023279672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023279672&partnerID=8YFLogxK

U2 - 10.1016/0091-3057(87)90371-6

DO - 10.1016/0091-3057(87)90371-6

M3 - Article

VL - 27

SP - 577

EP - 581

JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

SN - 0091-3057

IS - 3

ER -