Mice lacking factor VII develop normally but suffer fatal perinatal bleeding

Elliot D. Rosen, Joyce C.Y. Chan, Esohe Idusogie, Frédéric Clotman, George Vlasuk, Thomas Luther, Louise R. Jalbert, Sybille Albrecht, Liang Zhong, Ann Lissens, Luc Schoonjans, Lieve Moons, Désiré Collen, Francis J. Castellino, Peter Carmeliet

Research output: Contribution to journalArticle

169 Scopus citations

Abstract

Blood coagulation in vivo is initiated by factor VII (FVII) binding to its cellular receptor tissue factor (TF). FVII is the only known ligand for TF, so it was expected that FVII-deficient embryos would have a similar phenotype to TF-deficient embryos, which have defective vitello-embryonic circulation and die around 9.5 days of gestation. Surprisingly, we find that FVII-deficient (FVII-/-) embryos developed normally, FVII-/- mice succumbed perinatally because of fatal haemorrhaging from normal blood vessels. At embryonic day 9.5, maternal-fetal transfer of FVII was undetectable and survival of embryos did not depend on TF-FVII-initiated fibrin formation. Thus, the TF-/- embryonic lethal and the FVII-/- survival-phenotypes suggest a role for TF during embryogenesis beyond fibrin formation.

Original languageEnglish (US)
Pages (from-to)290-294
Number of pages5
JournalNature
Volume390
Issue number6657
DOIs
StatePublished - Nov 20 1997
Externally publishedYes

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    Rosen, E. D., Chan, J. C. Y., Idusogie, E., Clotman, F., Vlasuk, G., Luther, T., Jalbert, L. R., Albrecht, S., Zhong, L., Lissens, A., Schoonjans, L., Moons, L., Collen, D., Castellino, F. J., & Carmeliet, P. (1997). Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature, 390(6657), 290-294. https://doi.org/10.1038/36862