Mice with elevated muscle glycogen stores do not have improved exercise performance

Bartholomew A. Pederson, Carlie R. Cope, Jose M. Irimia, Jill M. Schroeder, Beth L. Thurberg, Anna A. DePaoli-Roach, Peter J. Roach

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Skeletal muscle glycogen is considered to be an important source of energy for contraction and increasing the level of the glucose polymer is generally thought to improve exercise performance in humans. A genetically modified mouse model (GSL30), which overaccumulates glycogen due to overexpression of a hyperactive form of glycogen synthase, was used to examine whether increasing the level of the polysaccharide enhances the ability of mice to run on a treadmill. The skeletal muscle of the GSL30 mice had large deposits of glycogen. There were no significant increases in the work performed by GSL30 mice as compared to their respective wild type littermates when exercised to exhaustion. The amount of muscle glycogen utilized by GSL30 mice, however, was greater, while the amount of liver glycogen consumed during exhaustive exercise was less than wild type animals. This result suggests that increased muscle glycogen stores do not necessarily improve exercise performance in mice.

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume331
Issue number2
DOIs
StatePublished - Jun 3 2005

Keywords

  • Exercise
  • Glycogen
  • Glycogen synthase
  • Mouse
  • Transgenic

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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